Results 41 to 50 of about 215,874 (309)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Diurnal patterns of salivary cytokines differentially correlate with greater fluctuations in cortisol and diet composition: A pilot study

Journal of Agriculture and Food Research
Chronic stress and elevated cortisol are associated with adverse metabolic profiles and lifestyle patterns, systemic low-grade inflammation, and increased chronic disease risk; however, it is less clear how the degree of cortisol fluctuations impacts ...
Catherine J. Andersen, Brian G. Walker, Thomas J. Karanian, Allison Sloan, Courtney Campbell, Lydia Dupree, Rachael Woodruff   +6 more
doaj   +1 more source

Low Urinary Free Cortisol as a Risk Factor for Patients with Variceal Bleeding

Medicina, 2023
Background and Objectives: Specificity and reliability issues of the current cortisol assessment methods lead to limitations on the accurate assessment of relative adrenal insufficiency.
Ioanna Aggeletopoulou, Efthymios P. Tsounis, Maria Kalafateli, Maria Michailidou, Maria Tsami, Konstantinos Zisimopoulos, Martha Mandellou, Georgia Diamantopoulou, Maria Kouskoura, Marina Michalaki, Catherine K. Markopoulou, Konstantinos Thomopoulos, Christos Triantos   +12 more
doaj   +1 more source

The Effects of Multivitamin Supplementation on Diurnal Cortisol Secretion and Perceived Stress [PDF]

, 2013
Recent evidence suggests that dietary intake of vitamins, in particular the B-vitamins including B6, B9 and B12 may have a number of positive effects on mood and stress.
White, David J., David Camfield, White, DJ, David White, Katherine Cox, Cox, Katherine, Cox, Katherine H., Kras, M, Erin Fogg, Stough, C, Marni Kras, Sali, Avni, Kras, Marni, Sali, A, Scholey, Andrew, Fogg, E, Sarris, Jerome (R18802), Avni Sali, Wetherell, Mark A., Sarris, Jerome, Pipingas, Andrew, Fogg, Erin, Camfield, DA, Jerome Sarris, Mark Wetherell, Con Stough, Camfield, David, Scholey, AB, White, David, Pipingas, A, Andrew Pipingas, Wetherell, Mark, Cox, KHM, Sarris, J, Scholey, Andrew B., Stough, Con K., Andrew Scholey, Stough, Con, Wetherell, MA   +38 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparison of salivary and serum cortisol levels in mechanically ventilated patients and non-critically ill patients [PDF]

Acute and Critical Care, 2020
Background Although the measuring free cortisol is ideal for assessment of hypothalamic-pituitary-adrenal function, it is not routinely measured. Salivary cortisol correlates well with the biologically active free cortisol. Therefore, this study measured
Jung Hee Kim, Yoon Ji Kim, Sang-Min Lee, Jinwoo Lee   +3 more
doaj   +1 more source

Cortisol awakening response in infants during the first six postnatal months and its relation to birth outcome [PDF]

, 2013
Context: The rise of cortisol concentrations after awakening is well documented in adults and children and commonly used as easily accessible marker of hypothalamic-pituitary-adrenal (HPA) reactivity.
Knierzinger, Nicole, Tegethoff, Marion, Meinlschmidt, Gunther, Meyer, Andrea H.   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Cortisol and 17-hydroxyprogesterone levels in saliva of healthy neonates - Normative data and relation to body mass index, arterial cord blood pH and time of sampling after birth [PDF]

, 2000
The measurement of cortisol and 17-hydroxyprogesterone (17-OHP) in saliva has become a reliable tool for both the scientist and the clinician for studying adrenal cortical function in the adult and the older child.
Meyer, Kerstin, Reich, Andrea, Kratzsch, Jürgen, Müller, Grit, Dressendörfer, Regina, Reiter, Hans-Ludwig, Klug, Ingo, Kühl, Gonne Peter, Kiess, Wieland, Strasburger, Christian   +9 more
core   +1 more source