Results 51 to 60 of about 246,209 (305)

Cortisol response to traumatic stress to predict PTSD symptom development – a systematic review and meta-analysis of experimental studies

European Journal of Psychotraumatology, 2023
Background: Pre-and post-traumatic hypothalamic–pituitary–adrenal (HPA) axis markers have been studied to predict posttraumatic stress disorder (PTSD) risk, but its acute reactivity cannot be measured in real-life settings.
Sinha Engel, Sebastian Laufer, Hannah Klusmann, Lars Schulze, Sarah Schumacher, Christine Knaevelsrud   +5 more
doaj   +1 more source

Daily life stress and the cortisol awakening response: testing the anticipation hypothesis [PDF]

, 2012
The cortisol awakening response (CAR) is a distinct facet of the circadian cortisol rhythm associated with various health conditions and risk factors.
Schlotz, Wolff, Daniel J Powell, Wolff Schlotz, Schlotz, W., Powell, Daniel J., Powell, D., Powell Daniel J., Schlotz Wolff, Powell, Daniel J   +8 more
core   +2 more sources

Analysis of cortisol levels in breast milk and blood serum in women with symptoms of postpartum depression

Medycyna Ogólna i Nauki o Zdrowiu, 2022
Introduction and objective Scientific studies report that the risk of symptoms of postpartum depression (PPD) can significantly reduce breastfeeding time. It has not yet been shown whether there is a difference in cortisol levels in breast milk and serum
Agnieszka Dombrowska-Pali, Agnieszka Chrustek, Grażyna Gebuza, Marzena Kaźmierczak   +3 more
doaj   +1 more source

The Effects of Multivitamin Supplementation on Diurnal Cortisol Secretion and Perceived Stress [PDF]

, 2013
Recent evidence suggests that dietary intake of vitamins, in particular the B-vitamins including B6, B9 and B12 may have a number of positive effects on mood and stress.
White, David J., David Camfield, White, DJ, David White, Katherine Cox, Cox, Katherine, Cox, Katherine H., Kras, M, Erin Fogg, Stough, C, Marni Kras, Sali, Avni, Kras, Marni, Sali, A, Scholey, Andrew, Fogg, E, Sarris, Jerome (R18802), Avni Sali, Wetherell, Mark A., Sarris, Jerome, Pipingas, Andrew, Fogg, Erin, Camfield, DA, Jerome Sarris, Mark Wetherell, Con Stough, Camfield, David, Scholey, AB, White, David, Pipingas, A, Andrew Pipingas, Wetherell, Mark, Cox, KHM, Sarris, J, Scholey, Andrew B., Stough, Con K., Andrew Scholey, Stough, Con, Wetherell, MA   +38 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Diurnal patterns of salivary cytokines differentially correlate with greater fluctuations in cortisol and diet composition: A pilot study

Journal of Agriculture and Food Research
Chronic stress and elevated cortisol are associated with adverse metabolic profiles and lifestyle patterns, systemic low-grade inflammation, and increased chronic disease risk; however, it is less clear how the degree of cortisol fluctuations impacts ...
Catherine J. Andersen, Brian G. Walker, Thomas J. Karanian, Allison Sloan, Courtney Campbell, Lydia Dupree, Rachael Woodruff   +6 more
doaj   +1 more source

Low Urinary Free Cortisol as a Risk Factor for Patients with Variceal Bleeding

Medicina, 2023
Background and Objectives: Specificity and reliability issues of the current cortisol assessment methods lead to limitations on the accurate assessment of relative adrenal insufficiency.
Ioanna Aggeletopoulou, Efthymios P. Tsounis, Maria Kalafateli, Maria Michailidou, Maria Tsami, Konstantinos Zisimopoulos, Martha Mandellou, Georgia Diamantopoulou, Maria Kouskoura, Marina Michalaki, Catherine K. Markopoulou, Konstantinos Thomopoulos, Christos Triantos   +12 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional study

BMC Endocrine Disorders, 2009
Background Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population.
Lindblad Ulf, Råstam Lennart, Gullberg Bo, Larsson Charlotte A   +3 more
doaj   +1 more source