Brain Sciences, 2021 The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic stress, which plays a key role in the pathophysiology of depression ...
Joanna Mikulska +3 more
doaj +4 more sources
The HPA Axis as Target for Depression. [PDF]
Curr Neuropharmacol, 2023 Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime prevalence of 20% and, thus, is one of the most prevalent mental health disorders worldwide.
Menke A.
europepmc +4 more sources
Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus-A Mini Review. [PDF]
Int J Mol SciChronic stress significantly contributes to the development of depressive disorders, with the hypothalamic–pituitary–adrenal (HPA) axis playing a central role in mediating stress responses.
Lei AA +6 more
europepmc +4 more sources
Reelin, the HPA Axis, and Chronic Stress: Implications for the Neurobiology of Depression [PDF]
Chronic StressStress and associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is central to major depression etiology, as HPA axis hyperactivity and hypercortisolism are common occurrences in individuals with depression.
Sophie A. Thom +5 more
doaj +2 more sources
The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk
Brain Sciences, 2020 Stress and Hypothalamic–Pituitary–Adrenal (HPA) axis dysregulation play a major role in various pathophysiological processes associated with both mood disorders and suicidal behavior.
Isabella Berardelli +5 more
doaj +2 more sources
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks
Molecular Systems Biology, 2020 Stress activates a complex network of hormones known as the hypothalamic–pituitary–adrenal (HPA) axis. The HPA axis is dysregulated in chronic stress and psychiatric disorders, but the origin of this dysregulation is unclear and cannot be explained by ...
Omer Karin +6 more
doaj +2 more sources
PLoS ONE, 2021 BackgroundEarly life exposure to adverse environments, and maternal stress in particular, has been shown to increase risk for metabolic diseases and neurobehavioral disorders.
Johanna R Jahnke +3 more
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Hypothalamic-Pituitary-Adrenal (HPA) Axis: Unveiling the Potential Mechanisms Involved in Stress-Induced Alzheimer's Disease and Depression. [PDF]
CureusThe hypothalamic-pituitary-adrenal (HPA) axis plays a pivotal role in the body's response to stress, orchestrating the release of glucocorticoids.
P S, Vellapandian C.
europepmc +2 more sources
HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity. [PDF]
Psychoneuroendocrinology, 2017 Inflammation is drawing attention as pathway between psychosocial stress and health, and basal HPA axis activity has been suggested to exert a consistent regulatory influence on peripheral inflammation. Here we studied the relationship between basal HPA axis activity and inflammatory and HPA axis acute stress reactivity.We recruited 48 healthy ...
Xuejie Chen +6 more
semanticscholar +3 more sources
Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis
Frontiers in Psychiatry, 2020 Stress in general, and early life stress in particular, has been associated with the development of anxiety and mood disorders. The molecular, biological and psychological links between stress exposure and the pathogenesis of anxiety and mood disorders ...
Gustavo E. Tafet, Charles B. Nemeroff
doaj +2 more sources