Results 41 to 50 of about 802,913 (283)
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao +10 more
wiley +1 more source
PLoS ONE, 2021 BackgroundEarly life exposure to adverse environments, and maternal stress in particular, has been shown to increase risk for metabolic diseases and neurobehavioral disorders.
Johanna R Jahnke +3 more
doaj +1 more source
HPA axis function in alcohol use disorder: A systematic review and meta-analysis
Addiction Neuroscience, 2023 Alcohol use disorder (AUD) is a culturally pervasive and often treatment resistant disorder. Stress is a major trigger for relapse in AUD. Allostasis in response to stress is governed by the hypothalamic-pituitary-adrenal axis (HPA axis).
Neil Dunne, Jo-Hanna Ivers
doaj +1 more source
3D Printing of Soft Robotic Systems: Advances in Fabrication Strategies and Future Trends
Advanced Robotics Research, EarlyView.Collectively, this review systematically examines 3D‐printed soft robotics, encompassing material selections, function integration, and manufacturing methodologies. Meanwhile, fabrication strategies are analyzed in order of increasing complexity, highlighting persistent challenges with proposed solutions.
Changjiang Liu +5 more
wiley +1 more source
Air pollution is associated with elevated HPA-Axis response to stress in anxious adolescent girls
Comprehensive Psychoneuroendocrinology, 2020 Research suggests that exposure to fine particulate air pollution (PM2.5) increases hypothalamic-pituitary-adrenal (HPA) axis activation in adults; it is unclear, however, whether PM2.5 is associated with HPA-axis functioning in psychosocial contexts ...
Jonas G. Miller +4 more
doaj +1 more source
The HPA-axis and immune function in burnout [PDF]
, 2007 Burnout results from chronic work stress. Its complaints may be related to HPA-axis disturbances or changes in immune function. In our studies the salivary cortisol awakening response, day-curve, and the suppressed level after dexamethasone intake were not different in a burned-out group compared to a control group.
Mommersteeg, P.M.C. +3 more
openaire +4 more sources
The cortisol awakening response: more than a measure of HPA axis function
, 2010 In most healthy people morning awakening is associated with a burst of cortisol secretion: the cortisol awakening response (CAR). It is argued that the CAR is subject to a range physiological regulatory influences that facilitate this rapid increase in ...
Evans, P. +4 more
core +1 more source
Advanced Science, EarlyView.A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang +4 more
wiley +1 more source