Results 41 to 50 of about 844,564 (283)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: an individual participant meta-analysis [PDF]

, 2012
The association between functioning of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages remains poorly understood. We carried out meta-analyses to test the hypothesis that dysregulation of the HPA axis, as indexed by ...
Kumari, Meena, Cooper, R, Kumari, M., Gallacher, John, Gardner, Michael P., Halcyon Study Team, Peeters, Geeske, Kuh, D., Gardner, Mike P, Ebrahim, Shah, Kumari, M, Cooper, R., Martin, Richard M, Ebrahim, Shah B J, Sayer, A.A., Gardner, M.P., Lightman, Stafford, Cooper, Rachel, Ben-Shlomo, Yoav, Ben-Shlomoa, Y., Gardner, Michael P, Gallacher, John Edward, Peeters, G, Martin, Richard M., Kivimaki, Mika, Kivimaki, M., Gallacher, J., Lightman, S., Deeg, D, Cooper, Cyrus, Ebrahim, S., Sayer, Avan Aihie, Kuh, Diana, Peeters, G., Deeg, D., Gallacher, J, Cooper, C., Deeg, Dorly, Ben-Shlomo, Y., Kuh, D, Deeg, D.J.H., Kivimaki, M, Aihie Sayer, A, Cooper, C, Martin, R.M., Lightman, Stafford L   +45 more
core   +1 more source

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source

Maternal precarity and HPA axis functioning shape infant gut microbiota and HPA axis development in humans.

PLoS ONE, 2021
BackgroundEarly life exposure to adverse environments, and maternal stress in particular, has been shown to increase risk for metabolic diseases and neurobehavioral disorders.
Johanna R Jahnke, Jeffrey Roach, M Andrea Azcarate-Peril, Amanda L Thompson   +3 more
doaj   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Air pollution is associated with elevated HPA-Axis response to stress in anxious adolescent girls

Comprehensive Psychoneuroendocrinology, 2020
Research suggests that exposure to fine particulate air pollution (PM2.5) increases hypothalamic-pituitary-adrenal (HPA) axis activation in adults; it is unclear, however, whether PM2.5 is associated with HPA-axis functioning in psychosocial contexts ...
Jonas G. Miller, Julia S. Gillette, Katharina Kircanski, Joelle LeMoult, Ian H. Gotlib   +4 more
doaj   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

The HPA-axis and immune function in burnout [PDF]

, 2007
Burnout results from chronic work stress. Its complaints may be related to HPA-axis disturbances or changes in immune function. In our studies the salivary cortisol awakening response, day-curve, and the suppressed level after dexamethasone intake were not different in a burned-out group compared to a control group.
Mommersteeg, P.M.C., Heijnen, C.J., Kavelaars, A.M.A.A., Van Doornen, L.J.P.   +3 more
openaire   +4 more sources

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

HPA AXIS ACTIVITY: A RESPONSE TO COMMENTS BY GUNTER SCHUMANN [PDF]

Addiction, 2006
Item does not contain ...
Huizink, A.C., Ferdinand, R.F., Ormel, J., Verhulst, F.C.   +3 more
openaire   +5 more sources