Results 51 to 60 of about 802,913 (283)

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

HPA AXIS ACTIVITY: A RESPONSE TO COMMENTS BY GUNTER SCHUMANN [PDF]

Addiction, 2006
Item does not contain ...
Huizink, A.C., Ferdinand, R.F., Ormel, J., Verhulst, F.C.   +3 more
openaire   +5 more sources

Stress, the hippocampus and the HPA axis: Implications for the development of psychotic disorders

, 2006
The experience of stress is commonly implicated in models of the onset of psychotic disorders. However, prospective studies investigating associations between biological markers of stress and the emergence of psychotic disorders are limited and ...
Katherine N. Thompson, Berger, Gregor, Gregor Berger, Wood, Stephen J., Pantelis, Christos, Phillips, Lisa J., Belinda Garner, Thompson, Kathrine N., Christos Pantelis, Garner, Belinda, Lisa J. Phillips, Stephen J. Wood, McGorry, Patrick D., Patrick D. Mcgorry   +13 more
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids and stress

Frontiers in Cellular Neuroscience, 2012
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated in a range of affective and stress-related disorders. The regulatory systems that control HPA activity are subject to modulation by environmental influences, and stressful
Ben eLevy, Jeffrey eTasker
doaj   +1 more source

GluN2A/ERK/CREB Signaling Pathway Involved in Electroacupuncture Regulating Hypothalamic-Pituitary-Adrenal Axis Hyperactivity

Frontiers in Neuroscience, 2021
The hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis caused by stress will inevitably disrupt the homeostasis of the neuroendocrine system and damage physiological functions.
Yu Wang, Jing Han, Jing Zhu, Mizhen Zhang, Minda Ju, Yueshan Du, Zhanzhuang Tian   +6 more
doaj   +1 more source

HPA-aksens dynamik - fra biologi til matemaik: The dynamics of the HPA-axis – from biology to mathematics [PDF]

, 2008
Focused on assisting mathematicians in constructing models of the HPA-axis, this report illustrates the regulating biological processes in the HPA-axis, under normal physiological conditions.
Hermann, Florian, Hansen, Tore Holm, Tawfik, Bassam, de Thurah, Lena, Nielsen, Malene, Katrine, Hammer   +5 more
core  

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Dysregulated Hypothalamic–Pituitary–Adrenal Axis Is Associated With Increased Inflammation and Worse Outcomes After Ischemic Stroke in Diabetic Mice

Frontiers in Immunology, 2022
Diabetic patients have larger infarcts, worse neurological deficits, and higher mortality rate after an ischemic stroke. Evidence shows that in diabetes, the hypothalamic–pituitary–adrenal (HPA) axis was dysregulated and levels of cortisol increased ...
Sehee Kim, Eun S. Park, Peng R. Chen, Eunhee Kim   +3 more
doaj   +1 more source

Not fade away: the HPA axis and depression [PDF]

Psychological Medicine, 2009
Salivary cortisol sampling has confirmed the presence of increased cortisol secretion in depression and has also revealed that some aspects of hypothalamo-pituitary-adrenal (HPA) axis disturbance have trait-like characteristics that may predict the risk of future illness.
openaire   +3 more sources