Results 61 to 70 of about 802,913 (283)
Advanced Science, EarlyView.Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi +8 more
wiley +1 more source
PLoS ONEThe two main pathways for hormonal stress response are the hypothalamic-pituitary- adrenal (HPA) axis and the sympathoadrenal (SA) axis. The HPA axis produces and secretes cortisol, while the SA axis produces and secretes the fast-acting catecholamines ...
Helen A Harris +4 more
doaj +1 more source
Glucocorticoid treatment:clinical consequences and effects on the HPA axis [PDF]
, 2022 This thesis comprehends a wide variety of angles on the hypothalamic-pituitary-adrenal (HPA) axis, our central stress response system. The studies described evaluate the residual function of the HPA axis when this has been lost due to disease or when the
Vulto, Annet; id_orcid, Vulto, Annet
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Advanced Science, EarlyView.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.Supramolecular 1‐D, 2‐D, and 3‐D networks comprised of ‐(‐O═Xe(O2)‐‐)‐∞ and ‐(‐Xe(O2)O‐‐‐HO(H)‐‐)‐∞ chains coordinated to polytopic N‐base ligands were synthesized and structurally characterized by X‐ray crystallography. Their Xe‐‐‐N and Xe‐‐‐O bonds are characteristic of σ–hole bonds in which the nucleophilic Lewis base sites of the N‐ligands, H2O ...
James T. Goettel +2 more
wiley +2 more sources
Advanced Science, EarlyView.Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen +11 more
wiley +1 more source
Telencephalic regulation of the HPA axis in birds
Neurobiology of Stress, 2021 The hypothalamo-pituitary-adrenal (HPA) axis is one of the major output systems of the vertebrate stress response. It controls the release of cortisol or corticosterone from the adrenal gland. These hormones regulate a range of processes throughout the brain and body, with the main function of mobilizing energy reserves to improve coping with a ...
openaire +3 more sources
Advanced Science, EarlyView.Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao +9 more
wiley +1 more source
Frontiers in NeuroscienceThe hypothalamus-pituitary-adrenal (HPA) and gut-brain axes are vital biological pathways in depression. The HPA axis regulates the body's stress response, and chronic stress can lead to overactivation of the HPA axis, resulting in elevated cortisol ...
Amanda Gollo Bertollo +3 more
doaj +1 more source
Early life stress, HPA axis, and depression. [PDF]
, 2011 Considerable evidence from various studies suggests a preeminent role for early adverse experiences in the development of psychopathology, especially depression.
Tofoli,Sandra Marcia de Carvalho +11 more
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