Results 11 to 20 of about 80,068 (296)
The HPA Axis as Target for Depression [PDF]
Current NeuropharmacologyAbstract: Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime prevalence of 20% and, thus, is one of the most prevalent mental health disorders worldwide. Many studies with a large number of patients support the notion that abnormalities of the hypothalamus-pituitaryadrenal (HPA) axis are crucial for the development of ...
Andreas Menke
exaly +4 more sources
Brain Sciences, 2021 The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic stress, which plays a key role in the pathophysiology of depression ...
Joanna Mikulska +2 more
exaly +3 more sources
Reelin, the HPA Axis, and Chronic Stress: Implications for the Neurobiology of Depression [PDF]
Chronic StressStress and associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is central to major depression etiology, as HPA axis hyperactivity and hypercortisolism are common occurrences in individuals with depression.
Sophie A. Thom +5 more
doaj +2 more sources
Bouncing back - trauma and the HPA-axis in healthy adults [PDF]
European Journal of Psychotraumatology, 2010 Dysregulation of the hypothalamic–pituitary–adrenal (HPA)-axis is thought to underlie stress-related psychiatric disorders such as posttraumatic stress disorder (PTSD). Some studies have reported HPA-axis dysregulation in trauma-exposed (TE)
Ellen Renée Klaassens
doaj +3 more sources
HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity [PDF]
Psychoneuroendocrinology, 2017 Inflammation is drawing attention as pathway between psychosocial stress and health, and basal HPA axis activity has been suggested to exert a consistent regulatory influence on peripheral inflammation. Here we studied the relationship between basal HPA axis activity and inflammatory and HPA axis acute stress reactivity.We recruited 48 healthy ...
Chen, Xuejie +6 more
openaire +4 more sources
HPA axis participates in the osteoporosis symptoms of Parkinson's disease
生物医学转化, 2023 Parkinson's disease (PD) is considered as an independent risk factor of osteoporosis, which reveals a common pathology within the two disorders. The dysfunction of hypothalamic-pituitary-adrenal axis (HPA axis), which has been frequently reported in PD ...
Yang Chunying +5 more
doaj +2 more sources
The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression. [PDF]
PLoS ONE, 2009 BackgroundIn this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated.Methodology/principal findingsIn 114 depressed inpatients suffering from unipolar or bipolar depression (
Cornelius Schüle +6 more
doaj +2 more sources
Not fade away: the HPA axis and depression [PDF]
Psychological Medicine, 2009 Salivary cortisol sampling has confirmed the presence of increased cortisol secretion in depression and has also revealed that some aspects of hypothalamo-pituitary-adrenal (HPA) axis disturbance have trait-like characteristics that may predict the risk of future illness.
Cowen, PJ
openaire +4 more sources
The different roles of glucocorticoids in the hippocampus and hypothalamus in chronic stress-induced HPA axis hyperactivity. [PDF]
PLoS ONE, 2014 Hypothalamus-pituitary-adrenal (HPA) hyperactivity is observed in many patients suffering from depression and the mechanism underling the dysfunction of HPA axis is not well understood.
Li-Juan Zhu +11 more
doaj +1 more source
Can variation in hypothalamic-pituitary-adrenal (HPA)-axis activity explain the relationship between depression and cognition in bipolar patients? [PDF]
PLoS ONE, 2012 Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is thought to be associated with more mood symptoms and worse cognitive functioning. This study examined whether variation in HPA axis activity underlies the association between mood symptoms
Marieke J van der Werf-Eldering +5 more
doaj +1 more source