Results 221 to 230 of about 50,392 (258)

De Novo Engineering of Corynebacterium glutamicum for l-Proline Production.

ACS Synthetic Biology, 2020
l-Proline is an important amino acid that has various industrial applications. Industrial l-proline-producing strains are obtained by the mutagenesis of Corynebacterium glutamicum. In this study, the optimized C.
Jiao Zhang, Fenghui Qian, Feng Dong, Qingzhuo Wang, Junjie Yang, Yu Jiang, Sheng Yang   +6 more
semanticscholar   +1 more source

Putrescine production by engineered Corynebacterium glutamicum

Applied Microbiology and Biotechnology, 2010
Here, we report the engineering of the industrially relevant Corynebacterium glutamicum for putrescine production. C. glutamicum grew well in the presence of up to 500 mM of putrescine. A reduction of the growth rate by 34% and of biomass formation by 39% was observed at 750 mM of putrescine. C.
Schneider, Jens, Wendisch, Volker F.
openaire   +2 more sources

Protein secretion inCorynebacterium glutamicum

Critical Reviews in Biotechnology, 2016
Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for the industrial production of amino acids, such as glutamate and lysine, for decades. Due to several characteristics - its ability to secrete properly folded and functional target proteins into culture broth, its low levels of endogenous extracellular proteins and its lack ...
Xiuxia, Liu, Wei, Zhang, Zihao, Zhao, Xiaofeng, Dai, Yankun, Yang, Zhonghu, Bai   +5 more
openaire   +2 more sources

Metabolic engineering Corynebacterium glutamicum to produce triacylglycerols

Metabolic Engineering, 2016
In this study, we metabolically engineered Corynebacterium glutamicum to produce triacylglycerols (TAGs) by completing and constraining a de novo TAG biosynthesis pathway. First, the plasmid pZ8_TAG4 was constructed which allows the heterologous expression of four genes: three (atf1 and atf2, encoding the diacylglycerol acyltransferase; pgpB, encoding ...
Plassmeier, Jens, Li, Youyuan, Rückert, Christian, Sinskey, Anthony J.   +3 more
openaire   +2 more sources

Overexpression of the key enzymes in the methylerythritol-4-phosphate pathway in Corynebacterium glutamicum for improving farnesyl diphosphate-derived terpene production.

Journal of Agricultural and Food Chemistry, 2020
A systematic and combinatorial optimization has been employed to metabolically engineer microbes for identifying key gene targets for overexpression to increase the intermediate pools for terpenoid production.
Hye-Kyung Lim, Jaehyun Park, H. Woo
semanticscholar   +1 more source

Metabolically engineered Corynebacterium glutamicum for bio-based production of chemicals, fuels, materials, and healthcare products.

Metabolic Engineering, 2018
Corynebacterium glutamicum is a major workhorse in industrial biotechnology. For the past several decades, this soil bacterium has been used to produce the amino acids l-glutamate and l-lysine at a level of 6 million tons per year. Utilizing novel genome
Judith Becker, C. Rohles, C. Wittmann
semanticscholar   +1 more source

Development of Metabolically Engineered Corynebacterium glutamicum for Enhanced Production of Cadaverine and Its Use for the Synthesis of Bio-Polyamide 510

ACS Sustainable Chemistry and Engineering, 2020
Lysine decarboxylases (LDCs) from Escherichia coli, Lactobacillus saerimneri, Streptomyces coelicolor, Selemonas ruminantium, Hafnia alvei, and Vibrio vulnificus were examined for their ability to enhance the fermentative production of cadaverine in ...
Hee Taek Kim, Kei-Anne Baritugo, S. Hyun, Tae Uk Khang, Y. Sohn, K. Kang, S. Jo, B. Song, Kyungmoon Park, Il-Kwon Kim, Y. Hwang, S. Lee, Si Jae Park, J. Joo   +13 more
semanticscholar   +1 more source

Osmosensing and osmosignaling in Corynebacterium glutamicum

Amino Acids, 2009
The Gram-positive soil bacterium Corynebacterium glutamicum is used in microbial biotechnology for the large-scale production of amino acids, e.g., L: -glutamate and L: -lysine. We have studied the response of this organism to hyperosmotic challenge at the level of both transcription and protein activity.
openaire   +2 more sources

Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production.

Metabolic Engineering, 2018
Methanol is a promising feedstock for bioproduction of fuels and chemicals, thus massive efforts have been devoted to engineering non-native methylotrophic platform microorganisms to utilize methanol.
Philibert Tuyishime, Yu Wang, Liwen Fan, Qiongqiong Zhang, Qinggang Li, Ping Zheng, Jibin Sun, Yanhe Ma   +7 more
semanticscholar   +1 more source

Metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid, a C5 dicarboxylic acid platform chemical.

Metabolic Engineering, 2019
Corynebacterium glutamicum was metabolically engineered for the production of glutaric acid, a C5 dicarboxylic acid that can be used as platform building block chemical for nylons and plasticizers. C. glutamicum gabT and gabD genes and Pseudomonas putida
Hee Taek Kim, Tae Uk Khang, Kei-Anne Baritugo, S. Hyun, K. Kang, S. Jung, B. Song, Kyungmoon Park, M. Oh, Gi Bae Kim, H. Kim, S. Lee, Si Jae Park, J. Joo   +13 more
semanticscholar   +1 more source