Results 121 to 130 of about 205,622 (234)

Futures of Everyday Life: A Qualitative Content Analysis of Future Personas in Scenarios

FUTURES &FORESIGHT SCIENCE, Volume 8, Issue 1, April 2026.
ABSTRACT Scenario reports, holding a long‐standing tradition in foresight and futures studies, act as an essential document for organizations to prepare for possible, plausible, and alternative futures. Focusing on descriptions and representations of everyday life, we examined 29 future persona narratives from six publications—covering a wide field ...
Gerhard Schönhofer, Pauli Komonen, Jan Oliver Schwarz, Laura Bechthold   +3 more
wiley   +1 more source

Germline genetic variants were interactively associated with somatic alterations in gastric cancer

Cancer Medicine, 2018
Genome‐wide association studies have identified several germline variants in gastric cancer. Meanwhile, sequencing studies have characterized extensive somatic alterations that arise during gastric carcinogenesis.
Xu Zhang, Yuzhuo Wang, Tian Tian, Gangqiao Zhou, Guangfu Jin   +4 more
doaj   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Papillary renal cell carcinoma with high‐ABCC2 shows an immune‐evasive profile associated with favorable response to immunotherapy

The Journal of Pathology, Volume 268, Issue 2, Page 188-199, February 2026.
Abstract The use of immune checkpoint inhibitors is a promising therapeutic strategy for metastatic papillary renal cell carcinoma (PRCC); however, predictive biomarkers remain limited. PRCCs with high ABCC2 expression represent an aggressive subset frequently associated with metastasis.
Vincent Francis Castillo, Abraam Zakhary, Fabio Rotondo, Caterina Di Ciano‐Oliveira, Malek Hamdani, Emelyn Adona, Theodorus van der Kwast, Kiril Trpkov, Rola Saleeb   +8 more
wiley   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

lncRNASNP2: an updated database of functional SNPs and mutations in human and mouse lncRNAs

Nucleic Acids Res., 2017
Long non-coding RNAs (lncRNAs) are emerging as important regulators in different biological processes through various ways. Because the related data, especially mutations in cancers, increased sharply, we updated the lncRNASNP to version 2 (http ...
Ya-Ru Miao, Wei Liu, Qiong Zhang, An-Yuan Guo   +3 more
semanticscholar   +1 more source

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

Statistical method on nonrandom clustering with application to somatic mutations in cancer

BMC Bioinformatics, 2010
Background Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells.
Rejto Paul A, Lunney Elizabeth A, Pavlicek Adam, Ye Jingjing, Teng Chi-Hse   +4 more
doaj   +1 more source

Long non-coding RNA FAM87A is associated with overall survival and promotes cell migration and invasion in gastric cancer

Frontiers in Oncology
Background The role of long non-coding RNAs (lncRNAs) in the invasion and metastasis of gastric cancer remains largely unclear. Methods Integrating transcriptome data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases ...
Xue Jiang, Xiaobin Wu, Manjiao Lu, Wenna Fan, Jing Song, Fangzhou Song   +5 more
semanticscholar   +1 more source

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

Advanced Science, Volume 13, Issue 3, 14 January 2026.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang, Shi‐Hao Bai, Shu‐Jin Song, Xiao‐Li Zhang, Xue‐Ying Shang, Zhao‐Ning Lu, Xiao‐Fang Cui, Xin‐Le Zhu, Ze‐Guang Han   +8 more
wiley   +1 more source