Results 121 to 130 of about 194,869 (207)

Biological implications of high-energy cosmic ray induced muon flux in the extragalactic shock model

, 2011
A ~ 62 My periodicity in fossil biodiversity has been observed in independent studies of paleontology databases over ~0.5Gy. The period and phase of this biodiversity cycle coincides with the oscillation of our solar system normal to the galactic disk ...
Adrian L. Melott, Alpen, Arens, Atri, Atri, Bailer-Jones, Chen, Cornette, Cucinotta, Dimitra Atri, Ferrari, Feulner, Gies, Groom, Hebbeker, Karam, Kirkby, Lieberman, McNulty, Medvedev, Melott, Melott, Melott, Melott, Melott, O'Brien, Pelliccioni, Rohde, Simonsen, Usoskin   +29 more
core   +1 more source

Cancer in Ancient Human Populations: Methods and Practice in Bioarchaeology and Paleopathology [PDF]

, 2020
Best Undergraduate Writing in Anthropology Award, 2019-2020Despite its prevalence in contemporary public health, research on the paleopathology of cancer is still extremely limited.
Gardner, Elijah
core  

lncRNASNP2: an updated database of functional SNPs and mutations in human and mouse lncRNAs

Nucleic Acids Res., 2017
Long non-coding RNAs (lncRNAs) are emerging as important regulators in different biological processes through various ways. Because the related data, especially mutations in cancers, increased sharply, we updated the lncRNASNP to version 2 (http ...
Ya-Ru Miao, Wei Liu, Qiong Zhang, An-Yuan Guo   +3 more
semanticscholar   +1 more source

Cohesins: Crossroad Between Cornelia de Lange Spectrum and Cancer Predisposition

American Journal of Medical Genetics Part A, Volume 197, Issue 8, August 2025.
ABSTRACT The cohesin complex plays crucial roles in DNA repair, chromatid separation, and gene transcription regulation. Pathogenic variants in cohesins or dysfunctional transcriptional regulators lead to cohesinopathies, a broader group of disorders including Cornelia de Lange Spectrum (CdLSp), for which the prevalence of cancer cases remains unclear.
Laura Rigotti, Stefano Rebellato, Antonella Lettieri, Silvia Castiglioni, Milena Mariani, Simona Totaro, Claudia Saitta, Cristina Gervasini, Grazia Fazio, Valentina Massa, Giovanni Cazzaniga, Angelo Selicorni   +11 more
wiley   +1 more source

Impact of cancer mutational signatures on transcription factor motifs in the human genome

BMC Medical Genomics, 2019
Background Somatic mutations in cancer genomes occur through a variety of molecular mechanisms, which contribute to different mutational patterns. To summarize these, mutational signatures have been defined using a large number of cancer genomes, and ...
Calvin Wing Yiu Chan, Zuguang Gu, Matthias Bieg, Roland Eils, Carl Herrmann   +4 more
doaj   +1 more source

Exploring somatic mutations in cancer with the COSMIC database and analysis tools

, 2022

openalex   +1 more source

Wilms Tumor in Children With AMER1/WTX Germline Pathogenic Variants: A Multicenter Case Series

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Background 10–15% of children with Wilms tumor (WT) have predisposing genetic syndromes. Somatic mutations are frequently identified; however, germline pathogenic variants in AMER1 are much less prevalent and are associated with osteopathia striata with cranial sclerosis (OSCS).
Insiyah Campwala, Jaclyn Schienda, Andrew J. Murphy, Basil Hashimi, Taylor Perry, Nicholas Cost, Junne Kamihara, Elizabeth A. Mullen, Teresa Santiago, Marcus M. Malek   +9 more
wiley   +1 more source

Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure

Genes and Environment
Background Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence of ITAC is strongly associated with
Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen, Lauri A. Aaltonen   +10 more
doaj   +1 more source

Efficient estimation of the distribution of time to composite endpoint when some endpoints are only partially observed.

, 2013
Two common features of clinical trials, and other longitudinal studies, are (1) a primary interest in composite endpoints, and (2) the problem of subjects withdrawing prematurely from the study. In some settings, withdrawal may only affect observation of
Daniel, Rhian M, Tsiatis, Anastasios A
core   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source