Clinical predictors of survival in malignant peripheral nerve sheath tumors of the head and neck: A cox regression and nomogram study [PDF]
Brazilian Journal of OtorhinolaryngologyObjectives: Malignant Peripheral Nerve Sheath Tumors (MPNST) are rapidly progressing Schwann cell neoplasms. This study aimed to develop a practical clinical nomogram that predicts prognosis in patients with Head and Neck MPNST (HN-MPNST) using the ...
Sun LiNa +4 more
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BMC Public HealthBackground Flight attendants face various risk factors in their working environments, particularly occupational exposure to cosmic radiation. This study aimed to assess cancer risk among air transportation industry workers, including flight attendants ...
Soojin Park +6 more
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A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer [PDF]
Frontiers in OncologyIntroductionClinical workflows to analyze variants of unknown significance (VUSs) found in clinical next generation sequencing (NGS) are labor intensive, requiring manual analysis of published data for each variant.
Amith Rangarajan +7 more
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Somatic Mutation Profiling and Therapeutic Landscape of Breast Cancer in the MENA Region [PDF]
CellsBreast cancer remains a major global health challenge. Yet, genomic data from Middle Eastern and North African (MENA) populations are limited, restricting insights into disease drivers and therapeutic opportunities in this demographic.
Dinesh Velayutham +7 more
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An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective
Discover OncologyBackground To explore the role of GAB2 in pan-cancer based on bioinformatics analysis. Methods Based on TCGA and GTEx databases, we used TIMER2.0 online analysis tool and R language to analyze the expression of GAB2 in pan-cancer.
Yi Yin +6 more
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Identification of Cancer-Associated Proteins in Colorectal Cancer Using Mass Spectrometry [PDF]
ProteomesBackground: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with a multifactorial etiology involving genetic and environmental factors. Advanced proteomics offers valuable insights into the molecular mechanisms of cancer,
Naoyuki Toyota +8 more
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Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs
Frontiers in Pharmacology, 2019 Despite the significant achievements in chemotherapy, cancer remains one of the leading causes of death. Target therapy revolutionized this field, but efficiencies of target drugs show dramatic variation among individual patients.
Marianna A. Zolotovskaia +13 more
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MoleculesThe lipid phosphatase Ship2 interacts with the EphA2 receptor by forming a heterotypic Sam (sterile alpha motif)–Sam complex. Ship2 works as a negative regulator of receptor endocytosis and consequent degradation, and anti-oncogenic effects in cancer ...
Marian Vincenzi +3 more
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Predicting high confidence ctDNA somatic variants with ensemble machine learning models [PDF]
Scientific ReportsCirculating tumour DNA (ctDNA) is a minimally invasive cancer biomarker that can be used to inform treatment of cancer patients. The utility of ctDNA as a cancer biomarker depends on the ability to accurately detect somatic variants associated with ...
Rugare Maruzani +3 more
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Unravelling the instability of mutational signatures extraction via archetypal analysis
Frontiers in Genetics, 2023 The high cosine similarity between some single-base substitution mutational signatures and their characteristic flat profiles could suggest the presence of overfitting and mathematical artefacts.
Corrado Pancotti +5 more
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