Results 21 to 30 of about 14,211 (155)

Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients

BMC Cancer, 2019
Background Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend our knowledge of pathogenicity ...
Takahiko Koyama, Kahn Rhrissorrakrai, Laxmi Parida   +2 more
doaj   +1 more source

Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples

BMC Bioinformatics, 2018
Background Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice.
Marcos Díaz-Gay, Maria Vila-Casadesús, Sebastià Franch-Expósito, Eva Hernández-Illán, Juan José Lozano, Sergi Castellví-Bel   +5 more
doaj   +1 more source

Prominent features of the amino acid mutation landscape in cancer. [PDF]

PLoS ONE, 2017
Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver mutations, and genetic signatures. Accordingly, each of these distinctions have been used to classify cancer subtypes and to reveal common features. Here,
Zachary A Szpiech, Nicolas B Strauli, Katharine A White, Diego Garrido Ruiz, Matthew P Jacobson, Diane L Barber, Ryan D Hernandez   +6 more
doaj   +1 more source

Identification of Shared Neoantigens in BRCA1-Related Breast Cancer

Vaccines, 2022
Personalized neoantigen-based cancer vaccines have been shown to be safe and immunogenic in cancer patients; however, the manufacturing process can be costly and bring about delays in treatment.
Lucksica Ruangapirom, Nannapat Sutivijit, Chinachote Teerapakpinyo, Apiwat Mutirangura, Chatchanan Doungkamchan   +4 more
doaj   +1 more source

Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census.

PLoS ONE, 2019
Genomics and genome screening are proving central to the study of cancer. However, a good appreciation of the protein structures coded by cancer genes is also invaluable, especially for the understanding of functions, for assessing ligandability of ...
Sony Malhotra, Ali F Alsulami, Yang Heiyun, Bernardo Montano Ochoa, Harry Jubb, Simon Forbes, Tom L Blundell   +6 more
doaj   +1 more source

CALR-ETdb, the database of calreticulin variants diversity in essential thrombocythemia

Platelets, 2022
Essential thrombocythemia (ET) is a blood cancer defined by a strong increase of platelet numbers. A quarter of patients suffering from ET show mutations in the last exon of calreticulin (CALR) gene.
Nora El Jahrani, Gabriel Cretin, Alexandre G. de Brevern   +2 more
doaj   +1 more source

Somatic Variations in Cervical Cancers in Indian Patients. [PDF]

PLoS ONE, 2016
There are very few reports that describe the mutational landscape of cervical cancer, one of the leading cancers in Indian women. The aim of the present study was to investigate the somatic mutations that occur in cervical cancer.
Poulami Das, Akanksha Bansal, Sudha Narayan Rao, Kedar Deodhar, Umesh Mahantshetty, Shyam K Shrivastava, Karthikeyan Sivaraman, Rita Mulherkar   +7 more
doaj   +1 more source

Comparative study of the evolution of cancer gene duplications across fish

Evolutionary Applications, 2022
Comparative studies of cancer‐related genes not only provide novel information about their evolution and function but also an understanding of cancer as a driving force in biological systems and species’ life histories. So far, these studies have focused
Ciara Baines, Richard Meitern, Randel Kreitsberg, Tuul Sepp   +3 more
doaj   +1 more source

Identification of candidate genes for lung cancer somatic mutation test kits

Genetics and Molecular Biology, 2013
Over the past three decades, mortality from lung cancer has sharply and continuously increased in China, ascending to the first cause of death among all types of cancer.
Yong Chen, Jian-Xin Shi, Xu-Feng Pan, Jian Feng, Heng Zhao   +4 more
doaj   +1 more source

Machine learning models-based on integration of next-generation sequencing testing and tumor cell sizes improve subtype classification of mature B-cell neoplasms

Frontiers in Oncology, 2023
BackgroundNext-generation sequencing (NGS) panels for mature B-cell neoplasms (MBNs) are widely applied clinically but have yet to be routinely used in a manner that is suitable for subtype differential diagnosis.
Yafei Mu, Yafei Mu, Yafei Mu, Yuxin Chen, Yuxin Chen, Yuxin Chen, Yuhuan Meng, Yuhuan Meng, Yuhuan Meng, Tao Chen, Tao Chen, Xijie Fan, Jiecheng Yuan, Jiecheng Yuan, Junwei Lin, Junwei Lin, Jianhua Pan, Jianhua Pan, Jianhua Pan, Guibin Li, Jinghua Feng, Kaiyuan Diao, Yinghua Li, Shihui Yu, Shihui Yu, Shihui Yu, Shihui Yu, Lingling Liu   +27 more
doaj   +1 more source