Results 21 to 30 of about 277,677 (243)

Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs

Frontiers in Pharmacology, 2019
Despite the significant achievements in chemotherapy, cancer remains one of the leading causes of death. Target therapy revolutionized this field, but efficiencies of target drugs show dramatic variation among individual patients.
Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Maxim I. Sorokin, Maxim I. Sorokin, Maxim I. Sorokin, Anna A. Emelianova, Nikolay M. Borisov, Nikolay M. Borisov, Denis V. Kuzmin, Pieter Borger, Andrew V. Garazha, Anton A. Buzdin, Anton A. Buzdin, Anton A. Buzdin   +13 more
doaj   +2 more sources

Cancer-Related Mutations in the Sam Domains of EphA2 Receptor and Ship2 Lipid Phosphatase: A Computational Study

Molecules
The lipid phosphatase Ship2 interacts with the EphA2 receptor by forming a heterotypic Sam (sterile alpha motif)–Sam complex. Ship2 works as a negative regulator of receptor endocytosis and consequent degradation, and anti-oncogenic effects in cancer ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +2 more sources

Unravelling the instability of mutational signatures extraction via archetypal analysis

Frontiers in Genetics, 2023
The high cosine similarity between some single-base substitution mutational signatures and their characteristic flat profiles could suggest the presence of overfitting and mathematical artefacts.
Corrado Pancotti, Cesare Rollo, Giovanni Birolo, Silvia Benevenuta, Piero Fariselli, Tiziana Sanavia   +5 more
doaj   +1 more source

Papillary Renal Cell Carcinoma: Demographics, Survival Analysis, Racial Disparities, and Genomic Landscape

Journal of Kidney Cancer and VHL, 2023
Papillary renal cell carcinoma (PRCC) is the second most common histological subtype of renal cell cancer. This research aims to present a large database study highlighting the demographic, clinical, and pathological factors, racial disparities ...
Asad Ullah, Abdul Qahar Khan Yasinzai, Naema Daino, Bisma Tareen, Zulfiqar Haider Jogezai, Haleema Sadia, Nimra Jamil, Girahnaz Baloch, Adil Karim, Kaleemullah Badini, Agha Wali, Abdul Waheed, Marjan Khan, Bina Asif, Kaleemullah Kakar, Saleh Heneidi, Feroze Sidhwa, Nabin R Karki   +17 more
doaj   +1 more source

The potential, analysis and prospect of ctDNA sequencing in hepatocellular carcinoma [PDF]

PeerJ, 2022
Background The genome map of hepatocellular carcinoma (HCC) is complex. In order to explore whether circulating tumor cell DNA (ctDNA) can be used as the basis for sequencing and use ctDNA to find tumor related biomarkers, we analyzed the mutant genes of
Yubo Ding, Jingwei Yao, Meiling Wen, Xiong Liu, Jialu Huang, Minghui Zhang, Yu Zhang, Yufan Lv, Zhuoyi Xie, JianHong Zuo   +9 more
doaj   +2 more sources

A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database

Cancers, 2021
Simple Summary Glioma patients that present a somatic mutation in the isocitrate dehydrogenase 1 (IDH1) gene have a significantly better prognosis and overall survival than patients with the wild-type genotype.
Amrit L Pappula, Shayaan Rasheed, Golrokh Mirzaei, Ruben C. Petreaca, R. Bouley   +4 more
semanticscholar   +1 more source

Data curation-research: practices of data standardization and exploration in a precision medicine database

New Genetics and Society, 2021
Key to precision medicine is the development of expert database projects that gather data, integrate them in the pre-existing database, and publish the product of their processing for others to make use of.
Niccolò Tempini
doaj   +1 more source

In-silico probing of AML related RUNX1 cancer-associated missense mutations: Predicted relationships to DNA binding and drug interactions

Frontiers in Molecular Biosciences, 2022
The molecular consequences of cancer associated mutations in Acute myeloid leukemia (AML) linked factors are not very well understood. Here, we interrogated the COSMIC database for missense mutations associated with the RUNX1 protein, that is frequently ...
Hanif Ullah, Hanif Ullah, Hanif Ullah, Baoyun Zhang, Baoyun Zhang, Narendra Kumar Sharma, Pierre D. McCrea, Pierre D. McCrea, Yogesh Srivastava, Yogesh Srivastava, Yogesh Srivastava   +10 more
doaj   +1 more source

The molecular genetics of RASopathies: An update on novel disease genes and new disorders

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 425-439, December 2022., 2022
Abstract Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK) cascade underlies the RASopathies, a family of clinically related disorders affecting development and growth. In RASopathies, increased RAS‐MAPK signaling can result from the upregulated activity of various RAS GTPases, enhanced function of proteins positively ...
Marco Tartaglia, Yoko Aoki, Bruce D. Gelb   +2 more
wiley   +1 more source

Comprehensive and user-analytics-friendly cancer patient database for physicians and researchers [PDF]

Proceedings of the 2022 International Conference on Computational Science and Computational Intelligence (CSCI), 2023
Nuanced cancer patient care is needed, as the development and clinical course of cancer is multifactorial with influences from the general health status of the patient, germline and neoplastic mutations, co-morbidities, and environment. To effectively tailor an individualized treatment to each patient, such multifactorial data must be presented to ...
arxiv   +1 more source