Results 31 to 40 of about 184,107 (180)
BMC Cancer, 2019 Background Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend our knowledge of pathogenicity ...
Takahiko Koyama +2 more
doaj +1 more source
BMC Bioinformatics, 2018 Background Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice.
Marcos Díaz-Gay +5 more
doaj +1 more source
Prominent features of the amino acid mutation landscape in cancer. [PDF]
PLoS ONE, 2017 Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver mutations, and genetic signatures. Accordingly, each of these distinctions have been used to classify cancer subtypes and to reveal common features. Here,
Zachary A Szpiech +6 more
doaj +1 more source
CALR-ETdb, the database of calreticulin variants diversity in essential thrombocythemia
Platelets, 2022 Essential thrombocythemia (ET) is a blood cancer defined by a strong increase of platelet numbers. A quarter of patients suffering from ET show mutations in the last exon of calreticulin (CALR) gene.
Nora El Jahrani +2 more
doaj +1 more source
Somatic Variations in Cervical Cancers in Indian Patients. [PDF]
PLoS ONE, 2016 There are very few reports that describe the mutational landscape of cervical cancer, one of the leading cancers in Indian women. The aim of the present study was to investigate the somatic mutations that occur in cervical cancer.
Poulami Das +7 more
doaj +1 more source
Comparative study of the evolution of cancer gene duplications across fish
Evolutionary Applications, 2022 Comparative studies of cancer‐related genes not only provide novel information about their evolution and function but also an understanding of cancer as a driving force in biological systems and species’ life histories. So far, these studies have focused
Ciara Baines +3 more
doaj +1 more source
Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics
Proteome Science, 2018 Background Protein kinase C ζ (PKCζ), an isoform of the atypical protein kinase C, is a pivotal regulator in cancer. However, the molecular and cellular mechanisms whereby PKCζ regulates tumorigenesis and metastasis are still not fully understood.
Chunyu Hou +6 more
doaj +1 more source
COSMIC: somatic cancer genetics at high-resolution
Nucleic Acids Res., 2016 COSMIC, the Catalogue of Somatic Mutations in Cancer (http://cancer.sanger.ac.uk) is a high-resolution resource for exploring targets and trends in the genetics of human cancer.
S. Forbes +18 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2023 PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the ...
Cathy E. Richards +15 more
semanticscholar +1 more source
Human Genomics, 2023 Mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3), also called extracellular regulated kinases (ERK2 and ERK1), are serine/threonine kinase activated downstream by the Ras/Raf/MEK/ERK signal transduction cascade that regulates a variety of ...
Maria Petrosino +7 more
semanticscholar +1 more source