Results 41 to 50 of about 194,869 (207)

A Spatial Simulation Approach to Account for Protein Structure When Identifying Non-Random Somatic Mutations [PDF]

, 2013
Background: Current research suggests that a small set of "driver" mutations are responsible for tumorigenesis while a larger body of "passenger" mutations occurs in the tumor but does not progress the disease.
Bjornson, Robert, Cheng, Yuwei, Cheung, Kei-Hoi, Modis, Yorgo, Ryslik, Gregory, Zelterman, Daniel, Zhao, Hongyu   +6 more
core   +2 more sources

Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)

International Journal of Molecular Sciences, 2023
PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the ...
Cathy E. Richards, Yasir Y. Elamin, A. Carr, K. Gately, S. Rafee, M. Cremona, E. Hanrahan, Robert Smyth, Daniel J Ryan, R. Morgan, Susan A. Kennedy, L. Hudson, J. Fay, K. O'Byrne, B. Hennessy, S. Toomey   +15 more
semanticscholar   +1 more source

Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics

Proteome Science, 2018
Background Protein kinase C ζ (PKCζ), an isoform of the atypical protein kinase C, is a pivotal regulator in cancer. However, the molecular and cellular mechanisms whereby PKCζ regulates tumorigenesis and metastasis are still not fully understood.
Chunyu Hou, Yuan Li, Huiqin Liu, Mengjiao Dang, Guoxuan Qin, Ning Zhang, Ruibing Chen   +6 more
doaj   +1 more source

Machine learning models-based on integration of next-generation sequencing testing and tumor cell sizes improve subtype classification of mature B-cell neoplasms

Frontiers in Oncology, 2023
BackgroundNext-generation sequencing (NGS) panels for mature B-cell neoplasms (MBNs) are widely applied clinically but have yet to be routinely used in a manner that is suitable for subtype differential diagnosis.
Yafei Mu, Yafei Mu, Yafei Mu, Yuxin Chen, Yuxin Chen, Yuxin Chen, Yuhuan Meng, Yuhuan Meng, Yuhuan Meng, Tao Chen, Tao Chen, Xijie Fan, Jiecheng Yuan, Jiecheng Yuan, Junwei Lin, Junwei Lin, Jianhua Pan, Jianhua Pan, Jianhua Pan, Guibin Li, Jinghua Feng, Kaiyuan Diao, Yinghua Li, Shihui Yu, Shihui Yu, Shihui Yu, Shihui Yu, Lingling Liu   +27 more
doaj   +1 more source

Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. [PDF]

, 2014
Understanding genetic aberrations in cancer leads to discovery of new targets for cancer therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully described. Therefore, patients with refractory advanced/metastatic HCC referred
Janku, Filip, Kaseb, Ahmed O, Kurzrock, Razelle, Tsimberidou, Apostolia M, Wolff, Robert A   +4 more
core   +3 more sources

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

Human Genomics, 2023
Mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3), also called extracellular regulated kinases (ERK2 and ERK1), are serine/threonine kinase activated downstream by the Ras/Raf/MEK/ERK signal transduction cascade that regulates a variety of ...
Maria Petrosino, L. Novak, A. Pasquo, Paola Turina, E. Capriotti, V. Minicozzi, V. Consalvi, R. Chiaraluce   +7 more
semanticscholar   +1 more source

COSMIC: somatic cancer genetics at high-resolution

Nucleic Acids Res., 2016
COSMIC, the Catalogue of Somatic Mutations in Cancer (http://cancer.sanger.ac.uk) is a high-resolution resource for exploring targets and trends in the genetics of human cancer.
S. Forbes, D. Beare, Harry Boutselakis, S. Bamford, Nidhi Bindal, J. Tate, C. Cole, Sari Ward, E. Dawson, Laura Ponting, R. Stefancsik, Bhavana Harsha, C. Kok, Mingming Jia, Harry C Jubb, Zbyslaw Sondka, Sam L. Thompson, Tisham De, P. Campbell   +18 more
semanticscholar   +1 more source

Computational Identification and Validation of Non-Synonymous SNPs in Progesterone Receptor Membrane Complex 1 Linked to Lung Cancer

International journal of experimental research and review, 2023
Numerous gene polymorphisms have been attributed to Lung cancer, but PGRMC1 (Progesterone receptor membrane component 1) is a lesser-known candidate among them.
Solaipriya Solairaja, Habeeb Shaik Mohideen, Sivaramakrishnan Venkatabalasubramanian   +2 more
semanticscholar   +1 more source

TNFAIP3 mutation may be associated with favorable overall survival for patients with T-cell lymphoma

Cancer Cell International, 2021
Background T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in developing targeted therapies.
Cunte Chen, Zheng Chen, Ling Huang, Lingling Zhou, Lihua Zhu, Sichu Liu, Gengxin Luo, Wenyu Li, Chengwu Zeng, Yangqiu Li   +9 more
doaj   +1 more source

Whole-exome sequencing and bioinformatic analyses revealed differences in gene mutation profiles in papillary thyroid cancer patients with and without benign thyroid goitre background

Frontiers in Endocrinology, 2023
BackgroundPapillary thyroid cancer (PTC) is the most common thyroid malignancy. Concurrent presence of cytomorphological benign thyroid goitre (BTG) and PTC lesion is often detected. Aberrant protein profiles were previously reported in patients with and
Zing Hong Eng, Mardiaty Iryani Abdullah, Mardiaty Iryani Abdullah, Khoon Leong Ng, Azlina Abdul Aziz, Nurul Hannis Arba’ie, Nurullainy Mat Rashid, Sarni Mat Junit   +7 more
doaj   +1 more source