Somatic Variations in Cervical Cancers in Indian Patients. [PDF]
PLoS ONE, 2016 There are very few reports that describe the mutational landscape of cervical cancer, one of the leading cancers in Indian women. The aim of the present study was to investigate the somatic mutations that occur in cervical cancer.
Poulami Das +7 more
doaj +1 more source
Target enrichment using parallel nanoliter quantitative PCR amplification [PDF]
, 2014 Background: Next generation targeted resequencing is replacing Sanger sequencing at high pace in routine genetic diagnosis. The need for well validated, high quality enrichment platforms to complement the bench-top next generation sequencing devices is ...
De Wilde, Bram +7 more
core +2 more sources
Comparative study of the evolution of cancer gene duplications across fish
Evolutionary Applications, 2022 Comparative studies of cancer‐related genes not only provide novel information about their evolution and function but also an understanding of cancer as a driving force in biological systems and species’ life histories. So far, these studies have focused
Ciara Baines +3 more
doaj +1 more source
Superluminous supernovae: No threat from Eta Carinae [PDF]
, 2007 Recently Supernova 2006gy was noted as the most luminous ever recorded, with a total radiated energy of ~10^44 Joules. It was proposed that the progenitor may have been a massive evolved star similar to eta Carinae, which resides in our own galaxy at a ...
Adrian L. Melott +5 more
core +1 more source
Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics
Proteome Science, 2018 Background Protein kinase C ζ (PKCζ), an isoform of the atypical protein kinase C, is a pivotal regulator in cancer. However, the molecular and cellular mechanisms whereby PKCζ regulates tumorigenesis and metastasis are still not fully understood.
Chunyu Hou +6 more
doaj +1 more source
Cell line name recognition in support of the identification of synthetic lethality in cancer from text [PDF]
, 2015 Motivation: The recognition and normalization of cell line names in text is an important task in biomedical text mining research, facilitating for instance the identification of synthetically lethal genes from the literature.
Ginter, Filip +5 more
core +2 more sources
Pockets as structural descriptors of EGFR kinase conformations [PDF]
, 2017 Epidermal Growth Factor Receptor (EGFR), a tyrosine kinase receptor, is one of the main tumor markers in different types of cancers. The kinase native state is mainly composed of two populations of conformers: active and inactive.
Barletta Roldan, Patricio German +4 more
core +1 more source
COSMIC: somatic cancer genetics at high-resolution
Nucleic Acids Res., 2016 COSMIC, the Catalogue of Somatic Mutations in Cancer (http://cancer.sanger.ac.uk) is a high-resolution resource for exploring targets and trends in the genetics of human cancer.
S. Forbes +18 more
semanticscholar +1 more source
Complex-based analysis of dysregulated cellular processes in cancer [PDF]
, 2014 Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes.
Khanna, Kum Kum +6 more
core +1 more source
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Nucleic Acids Res., 2010 COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136 000 coding mutations in almost 542 000 tumour samples; of the 18 490 genes documented, 4803 (26 ...
S. Forbes +13 more
semanticscholar +1 more source