Results 41 to 50 of about 184,107 (180)

Machine learning models-based on integration of next-generation sequencing testing and tumor cell sizes improve subtype classification of mature B-cell neoplasms

Frontiers in Oncology, 2023
BackgroundNext-generation sequencing (NGS) panels for mature B-cell neoplasms (MBNs) are widely applied clinically but have yet to be routinely used in a manner that is suitable for subtype differential diagnosis.
Yafei Mu, Yafei Mu, Yafei Mu, Yuxin Chen, Yuxin Chen, Yuxin Chen, Yuhuan Meng, Yuhuan Meng, Yuhuan Meng, Tao Chen, Tao Chen, Xijie Fan, Jiecheng Yuan, Jiecheng Yuan, Junwei Lin, Junwei Lin, Jianhua Pan, Jianhua Pan, Jianhua Pan, Guibin Li, Jinghua Feng, Kaiyuan Diao, Yinghua Li, Shihui Yu, Shihui Yu, Shihui Yu, Shihui Yu, Lingling Liu   +27 more
doaj   +1 more source

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Nucleic Acids Res., 2010
COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136 000 coding mutations in almost 542 000 tumour samples; of the 18 490 genes documented, 4803 (26 ...
S. Forbes, Nidhi Bindal, S. Bamford, C. Cole, C. Kok, D. Beare, Mingming Jia, Rebecca Shepherd, Kenric Leung, A. Menzies, J. Teague, P. Campbell, M. Stratton, P. Futreal   +13 more
semanticscholar   +1 more source

Computational Identification and Validation of Non-Synonymous SNPs in Progesterone Receptor Membrane Complex 1 Linked to Lung Cancer

International journal of experimental research and review, 2023
Numerous gene polymorphisms have been attributed to Lung cancer, but PGRMC1 (Progesterone receptor membrane component 1) is a lesser-known candidate among them.
Solaipriya Solairaja, Habeeb Shaik Mohideen, Sivaramakrishnan Venkatabalasubramanian   +2 more
semanticscholar   +1 more source

Identification of candidate genes for lung cancer somatic mutation test kits

Genetics and Molecular Biology, 2013
Over the past three decades, mortality from lung cancer has sharply and continuously increased in China, ascending to the first cause of death among all types of cancer.
Yong Chen, Jian-Xin Shi, Xu-Feng Pan, Jian Feng, Heng Zhao   +4 more
doaj   +1 more source

Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor

Life Science Alliance, 2023
This work identifies missense mutations in the translation initiation factor EIF4G2 gene in cancer, showing loss-of-function effects on binding to interacting proteins and translational activity.
Sara Meril, Marcela Bahlsen, Miriam Eisenstein, A. Savidor, Y. Levin, S. Bialik, S. Pietrokovski, Adi Kimchi   +7 more
semanticscholar   +1 more source

TNFAIP3 mutation may be associated with favorable overall survival for patients with T-cell lymphoma

Cancer Cell International, 2021
Background T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in developing targeted therapies.
Cunte Chen, Zheng Chen, Ling Huang, Lingling Zhou, Lihua Zhu, Sichu Liu, Gengxin Luo, Wenyu Li, Chengwu Zeng, Yangqiu Li   +9 more
doaj   +1 more source

Whole-exome sequencing and bioinformatic analyses revealed differences in gene mutation profiles in papillary thyroid cancer patients with and without benign thyroid goitre background

Frontiers in Endocrinology, 2023
BackgroundPapillary thyroid cancer (PTC) is the most common thyroid malignancy. Concurrent presence of cytomorphological benign thyroid goitre (BTG) and PTC lesion is often detected. Aberrant protein profiles were previously reported in patients with and
Zing Hong Eng, Mardiaty Iryani Abdullah, Mardiaty Iryani Abdullah, Khoon Leong Ng, Azlina Abdul Aziz, Nurul Hannis Arba’ie, Nurullainy Mat Rashid, Sarni Mat Junit   +7 more
doaj   +1 more source

PanCNV Explorer: A pan-cancer database for copy number variations.

medRxiv
Introduction: Copy number variations (CNVs) are structural genomic alterations that involve changes in the number of copies of specific DNA regions.
Kevin Kornrumpf, Jürgen Dönitz
semanticscholar   +1 more source

Whole exome sequencing in the rat

BMC Genomics, 2018
Background The rat genome was sequenced in 2004 with the aim to improve human health altered by disease and environmental influences through gene discovery and animal model validation.
Julie F. Foley, Dhiral P. Phadke, Owen Hardy, Sara Hardy, Victor Miller, Anup Madan, Kellie Howard, Kimberly Kruse, Cara Lord, Sreenivasa Ramaiahgari, Gregory G. Solomon, Ruchir R. Shah, Arun R. Pandiri, Ronald A. Herbert, Robert C. Sills, B. Alex Merrick   +15 more
doaj   +1 more source

Mutational landscape differences between young-onset and older-onset breast cancer patients

BMC Cancer, 2020
Background The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for ...
Nicole E. Mealey, Dylan E. O’Sullivan, Joy Pader, Yibing Ruan, Edwin Wang, May Lynn Quan, Darren R. Brenner   +6 more
doaj   +1 more source