Results 101 to 110 of about 1,596,449 (302)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The "ComPAS Trial" combined treatment model for acute malnutrition: study protocol for the economic evaluation

open access: yesTrials, 2018
Background Acute malnutrition is currently divided into severe (SAM) and moderate (MAM) based on level of wasting. SAM and MAM currently have separate treatment protocols and products, managed by separate international agencies.
Natasha Lelijveld   +6 more
doaj   +1 more source

Discounting the distant future: How much does model selection affect the certainty equivalent rate? [PDF]

open access: yes
Evaluating investments with long-term consequences using discount rates that decline with the time horizon, (Declining Discount Rates or DDRs) means that future welfare changes are of greater consequence in present value terms.
B. Groom   +3 more
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

On the Foundation of Guidelines for Health Economic Evaluation [PDF]

open access: yes
In recent years, there has been increased interest in setting up guidelines for carrying out cost-effectiveness analysis of medical interventions, and some such guidelines have indeed been established.
Hans Keiding
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Micro-costing and a cost-consequence analysis of the 'Girls Active' programme: A cluster randomised controlled trial.

open access: yesPLoS ONE, 2019
Physical inactivity has been identified as a leading risk factor for premature mortality globally, and adolescents, in particular, have low physical activity levels. Schools have been identified as a setting to tackle physical inactivity.
Joanna M Charles   +9 more
doaj   +1 more source

Quantitative Assessment of the Impact of Automatic Static Analysis Issues on Time Efficiency [PDF]

open access: yes, 2011
Background: Automatic Static Analysis (ASA) tools analyze source code and look for code patterns (aka smells) that might cause defective behavior or might degrade other dimensions of software quality, e.g. efficiency.
Morisio, Maurizio   +2 more
core  

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