Results 41 to 50 of about 27,108,475 (305)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Cognition and Cost-Benefit Analysis

SSRN Electronic Journal, 1999
Abstract Cost‐benefit analysis is often justified on conventional economic grounds, as a way of preventing inefficiency. But it is most plausibly justified on cognitive grounds—as a way of counteracting predictable problems in individual and social cognition.
openaire   +2 more sources

An Analysis of the Cost and Benefit of Search Interactions [PDF]

Proceedings of the 2016 ACM International Conference on the Theory of Information Retrieval, 2016
Interactive Information Retrieval (IR) systems often provide various features and functions, such as query suggestions and relevance feedback, that a user may or may not decide to use. The decision to take such an option has associated costs and may lead to some benefit. Thus, a savvy user would take decisions that maximises their net benefit.
Leif Azzopardi, Guido Zuccon
openaire   +5 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Economic Evaluation of Health Interventions: A Critical Review

Iranian Journal of Public Health, 2022
Background: Economic evaluation is used for the optimal allocation of resources in the health sector. While a large number of economic evaluation studies have been conducted, there is less critical review of these studies.
Ali Mohammad Mosadeghrad, Ebrahim Jaafaripooyan, Mahmoud Zamandi   +2 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Incremental expenditure for hospital care associated infections [PDF]

Al Ameen Journal of Medical Sciences, 2019
Background: Hospital care associated infections [HAI] are time varying and they substantially increase the burden for the patients, relatives, Payers, Third party Administrators and Hospital Administrators.
K.S. Sarala, V. Narendranath, B.S. Nanda Kumar   +2 more
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Cost-benefit analysis of flight extended operations (ETOPS) for Garuda Indonesia airways

SHS Web of Conferences, 2018
Garuda Indonesia reducing the flight cost used flight extended operations (ETOPS). ETOPS can reduce travel time and fuel consumption. The cost-benefit analysis was conducted to compare the flight between NON ETOPS flight and ETOPS flight Cengkareng ...
Purwaningsih Ratna, Pritandari Lakshita, Santoso Haryo   +2 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source