Results 51 to 60 of about 71,972 (342)

Asymmetrical hybridization and gene flow between Eisenia andrei and E. fetida lumbricid earthworms [PDF]

open access: yes, 2018
Uniformly pigmented Eisenia andrei (Ea) and striped E. fetida (Ef) lumbricid earthworms are hermaphrodites capable of self-fertilization, cross-fertilization, and asymmetrical hybridization.
Bigaj, Janusz   +3 more
core   +1 more source

Nature‐Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes

open access: yesAdvanced Science, EarlyView.
The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang   +12 more
wiley   +1 more source

Switchable Coumarins for Ratiometric pH Sensing

open access: yesFrontiers in Materials, 2021
A fluorescent chromophore and a pH-sensitive heterocycle were integrated within a single covalent skeleton to generate four molecular switches with ratiometric fluorescence response.
Mercedes M. A. Mazza   +7 more
doaj   +1 more source

Effect of sensitization on the electrochemical properties of nanostructured NiO [PDF]

open access: yes, 2018
Screen-printed NiO electrodes were sensitized with 11 different dyes and the respective electrochemical properties were analyzed in a three-electrode cell with the techniques of cyclic voltammetry and electrochemical impedance spectroscopy.
Barolo, Claudia   +3 more
core   +1 more source

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

open access: yesAdvanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang   +11 more
wiley   +1 more source

The underappreciated diversity of furanocoumarins in grapefruits revealed by MassQL filtered molecular networking

open access: yesFood Chemistry: X
Grapefruit is one of the most popular Citrus fruits, which is beneficial for health. Coumarins are the main secondary metabolites in grapefruits. The structural and functional diversity makes the comprehensive determination of coumarins in complex system
Shilin Gong   +7 more
doaj   +1 more source

Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition [PDF]

open access: yes, 2018
Antibiotic resistance is a growing threat worldwide, causing serious problems in the treatment of microbial infections. The discovery and development of new drugs is urgently needed to overcome this problem which has greatly undermined the clinical ...
Gutiérrez-Barranquero, José A.   +3 more
core   +2 more sources

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu   +8 more
wiley   +1 more source

Mapping the Biotransformation of Coumarins through Filamentous Fungi

open access: yesMolecules, 2019
Natural coumarins are present in remarkable amounts as secondary metabolites in edible and medicinal plants, where they display interesting bioactivities.
Jainara Santos do Nascimento   +5 more
doaj   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

open access: yesAdvanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang   +23 more
wiley   +1 more source

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