Results 41 to 50 of about 25,230 (162)

Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives

Scientifica, 2016
Semisynthetic and commercial coumarins were investigated for their antibacterial and adjuvant properties with antibiotic agents against norfloxacin, erythromycin, and tetracycline resistant Staphylococcus aureus as based on efflux mechanisms.
Rodrigo Santos Aquino de Araújo, José Maria Barbosa-Filho, Marcus Tullius Scotti, Luciana Scotti, Ryldene Marques Duarte da Cruz, Vivyanne dos Santos Falcão-Silva, José Pinto de Siqueira-Júnior, Francisco Jaime Bezerra Mendonça-Junior   +7 more
doaj   +1 more source

Effects of Osthol Isolated from Cnidium monnieri Fruit on Urate Transporter 1

Molecules, 2018
(1) Background: Crude drugs used in traditional Japanese Kampo medicine or folk medicine are major sources of new chemical entities for drug discovery.
Yuusuke Tashiro, Ryo Sakai, Tomoko Hirose-Sugiura, Yukio Kato, Hirotaka Matsuo, Tappei Takada, Hiroshi Suzuki, Toshiaki Makino   +7 more
doaj   +1 more source

Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19

Molecules, 2019
Parvovirus B19 (B19V) is a human pathogenic virus associated with a wide range of clinical conditions. Currently, there are no recognized antiviral drugs for B19V treatment; therefore, efforts in the search for compounds inhibiting B19V replication are ...
Ilaria Conti, Rita Morigi, Alessandra Locatelli, Mirella Rambaldi, Gloria Bua, Giorgio Gallinella, Alberto Leoni   +6 more
doaj   +1 more source

Knoevenagel Reaction in [MMIm][MSO4]: Synthesis of Coumarins

Molecules, 2011
The ionic liquid 1,3-dimethylimidazolium methyl sulfate, [MMIm][MSO4], together with a small amount of water (the amount taken up by the ionic liquid upon exposure to air), acts efficiently as both solvent and catalyst of the Knoevenagel condensation ...
Emilia Tojo, Francisco Santamarta, Pedro Verdía   +2 more
doaj   +1 more source

Coumarins in the tumor-immune application: from molecular mechanisms to therapeutic innovations

Frontiers in Immunology
Coumarin compounds represent a class of natural or synthetic molecules characterized by a benzo-α-pyrone skeleton. Their diverse substituents and extensive biological activities have garnered significant attention in the fields of anti-tumor therapy and ...
Yufan Zhao, Lingjie Jing, Leng Han, Cheng Guo, Quanjun Yang   +4 more
doaj   +1 more source

Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer—An in Vitro Model for Blood-Brain Barrier Permeability

Molecules, 2015
Angelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine, is reported to have central nervous system activities. The purpose of this study was to characterize the blood-brain barrier permeability of twelve coumarins from APR ...
Yan-Fang Yang, Wei Xu, Wei Song, Min Ye, Xiu-Wei Yang   +4 more
doaj   +1 more source

Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena Harmandiana

Molecules, 2019
Seven compounds, carbazole alkaloids (heptaphylline, 7-methoxyheptaphylline, 7-methoxymukonal) and coumarins (clausarin, dentatin, nordentatin, and xanthoxyletin), were isolated from the root bark of Clausena harmandiana.
Porntip Jantamat, Natthida Weerapreeyakul, Ploenthip Puthongking   +2 more
doaj   +1 more source

Comparison of the bioactive chemical components and antioxidant activities in three tissues of six varieties of Citrus grandis ‘Tomentosa’ fruits

International Journal of Food Properties, 2019
The total phenolic, flavonoid, coumarin, and volatile contents and antioxidant activities in three tissues of six Citrus grandis ‘Tomentosa’ (CGT) fruit varieties were investigated. Two flavones, 3 coumarins and 147 volatiles were identified. The exocarp
Ruiyi Fan, Congyi Zhu, Diyang Qiu, Jiwu Zeng   +3 more
doaj   +1 more source

Lipophilicity of natural coumarines

Current Issues in Pharmacy and Medical Sciences, 2012
Coumarins are the class of natural compounds found in many medicinal plants with broad spectrum of activity. Many of them are also used as pharmaceutical substances, so there is an urgent need for efficient method of their isolation from the natural ...
Dariusz Matosiuk, Daniel Gralak, Marta Ryznar   +2 more
doaj  

Anti-inflammatory and cytotoxic effects of Jatropha podagrica extracts on skin cancer

Research in Pharmaceutical Sciences
Background and purpose: Jatropha podagrica Hook, belongs to the Euphorbiaceae family, which possesses anticancer activities and is traditionally applied to treat skin diseases. No reports of J. podagrica anti-neoplastic activity on an amelanotic melanoma
Reawfang Sriyom, Arunporn Itharat, Onmanee Prajuabjinda, Pakakrong Thongdeeying, Srisopa Ruangnoo, Sunita Makchuchit, Pranporn Kuropakornpong, Kanyarat Namphonsaen, Perika Monkanna, Neal M. Davies   +9 more
doaj   +1 more source