Results 31 to 40 of about 24,198 (212)

Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol

Frontiers in Pharmacology, 2017
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements.
Vanessa Gonzalez-Covarrubias, Javier Urena-Carrion, Beatriz Villegas-Torres, J. Eduardo Cossío-Aranda, Sergio Trevethan-Cravioto, Raul Izaguirre-Avila, O. Javier Fiscal-López, Xavier Soberon   +7 more
doaj   +1 more source

Bioactivity and toxicity of coumarins from African medicinal plants

Frontiers in Pharmacology
Introduction: Coumarins are naturally occuring metabolites from plants and a few micro-organisms. They have been widely used in the food and drug industry in their natural or synthetic forms.
Godwin Anywar, Emmanuel Muhumuza
doaj   +1 more source

Upcycling Water Pollutants Into Long‐Chain Polymers via Synergistic Interfacial Dechlorination and Organic Radical Stabilization

Angewandte Chemie, EarlyView.
HEO‐regulated electronic structure drives nonradical PI activation, promoting ETP‐mediated polymerization of 4CP into high‐molecular‐weight products with enhanced surface enrichment. Concurrent dechlorination occurs via radical coupling and •OHads attack, enabling efficient carbon retention and selective product evolution at the liquid–solid interface.
Ziwei Yao, Yidi Chen, Penghui Shao, Jian Liu, Xiaodan Wang, Kunsheng Hu, Xubiao Luo, Nanqi Ren, Xiaoguang Duan   +8 more
wiley   +2 more sources

Synthesis and antioxidant activity of novel 8-formyl-4-substitued coumarins

Bulletin of the Chemical Society of Ethiopia, 2018
4-Methyl-8-formyl- and 4-phenyl-8-formyl coumarins have been synthesized by Pechmann reaction using oxalic acid catalyst for the first time. 4-Propyl-7-hydroxy-, and 4-methyl-7-methoxy coumarins have also been accomplished by this catalyst for the first ...
H. Ç. Onar, B. A.Vardar
doaj   +1 more source

Perilipin‐2‐Anchored Lipid Droplet‐Targeting Phototheranostics

Angewandte Chemie, EarlyView.
This study reports two NIR theranostic dyes, C‐BDP‐OH and C‐BDP‐OMe. C‐BDP‐OMe targets lipid droplets via a dual‐anchoring mechanism with PLIN2, enabling wash‐free tumor imaging. With 62.6% photothermal conversion efficiency, it achieves tumor ablation by downregulating PLIN2, disrupting LD‐mitochondria crosstalk, and triggering apoptosis and ...
Lipeng Zhang, Jiyoung Yoo, Juan Bai, Sunghyun Kim, Yesim Bakan, Yongbin Zhang, Fangjun Huo, Jingying Zhou, Caixia Yin, Jong Seung Kim   +9 more
wiley   +2 more sources

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Structural Control of Dual Emission in Coumarin Fluorophores for Visualizing Protein Droplet Maturation

Angewandte Chemie, EarlyView.
A coumarin‐based dual‐emission fluorophore was designed to visualize the maturation of protein liquid droplets. Upon covalent conjugation to droplet‐forming proteins, ratiometric fluorescence imaging allowed real time monitoring of droplet maturation. This probe is applicable to the analysis of droplet formation and maturation mechanisms, as well as to
Tomoya Yamamoto, Yusei Otsuka, Asuka Mori, Yuichiro Hori, Yuma Yamamoto, Motonari Uesugi, Kazuya Kikuchi   +6 more
wiley   +2 more sources

The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins

Acta Pharmaceutica Sinica B
Coumarins, derived from the phenylpropanoid pathway, represent one of the primary metabolites found in angiosperms. The alignment of the tetrahydropyran (THP) and tetrahydrofuran (THF) rings with the lactone structure results in the formation of at least
Qien Li, Yiqun Dai, Xin-Cheng Huang, Lanlan Sun, Kaixuan Wang, Xiao Guo, Dingqiao Xu, Digao Wan, Latai An, Zixuan Wang, Huanying Tang, Qi Qi, Huihui Zeng, Minjian Qin, Jia-Yu Xue, Yucheng Zhao   +15 more
doaj   +1 more source

Application of solid-phase extraction for isolation of coumarins from wine samples

Nova Biotechnologica et Chimica, 2019
Coumarins can be as a result wine storage and aging in wood drums and they can affect organoleptic characteristics of wine. The aim of this work was to determine the content of coumarins in wine samples originated from Slovak Tokaj wine region.
Hroboňová Katarína, Špačková Andrea, Ondáková Martina   +2 more
doaj   +1 more source

Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

Advanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen, Xiaoyu Wang, Jilin Fan, Bi Wang, Hanghang Fang, Yurui Wang, Hao Cui, Mohammad Roufarshbaf, Ekaterina Savina, Alexandra Valeske, Quim Peña, Yang Shi, Andreas Herrmann, Twan Lammers, Mathias Hornef, Roman Barmin, Thomas Lisson, Georg Schmitz, Anne Rix, Fabian Kiessling   +19 more
wiley   +1 more source