Results 61 to 70 of about 6,129,482 (309)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Who You Gonna Call? Insights from the ECJ’s Case C-551/21 on the Signature of International Agreements

European Papers
(Series Information) European Papers - A Journal on Law and Integration, 2024 9(1), 121-129 | European Forum Insight of 18 June 2024 | (Table of Contents) I. Introduction. - II. Signature of international agreements: the (in)consistent practice.
Felipe Tomazini de Souza
doaj   +1 more source

Contributions of ʿUrf (Custom) to Politics and Political Structure with a View to Shia Jurisprudence (From the Perspective of Shia Jurists) [PDF]

Journal of Islamic Political Studies
Custom or customary practice (ʿurf) is an important phenomenon in Shiite jurisprudence, which became more intertwined with its discourse after the dominance of the Usuli scholars over the Akhbari tradition.
Omid Khalili-Mehr, Majid Tavasoli Roknabadi, Ali Shirkhani   +2 more
doaj   +1 more source

A preliminary assessment of water partitioning and ecohydrological coupling in northern headwaters using stable isotopes and conceptual runoff models [PDF]

, 2015
Funded by European Research Council ERC. Grant Number: GA 335910 VEWA Swedish Science Foundation (SITES) Future Forest Formas (ForWater) SKB the Kempe foundation Environment Canada the Garfield Weston Foundation the Natural Sciences and Engineering ...
Buttle, James, Carey, Sean K., Gabor, Rachel S., Laudon, Hjalmar, McNamara, James P., Mitchell, Carl P.J., Soulsby, Chris, Spence, Chris, Tetzlaff, Doerthe, Van Huijgevoort, Marjolein H. J.   +9 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Meaning of Council in the Iranian Experience [PDF]

سپهر سیاست, 2015
The concept of the council, an Islamic instruction along with the other religious instructions, enjoys appropriate conceptual and theoretical potential which are along the discussion of the religious democracy. Although in the religious texts the concept 
Mansour  Mirahmadi
doaj  

English as a foreign language (EFL) review: final report [PDF]

, 2000
The Further Education Funding Council (the Council) has undertaken a review of the position of English as foreign language (EFL) qualifications for the college year 2000-01 and beyond.

core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Influencia mediática de la investigación en Humanidades y Ciencias Sociales. Estudio de la repercusión de las publicaciones científicas del Consejo Superior de Investigaciones Científicas (CSIC) en Altmetric = The media influence of research in Humanities and Social Science. Study of the impact of Spanish National Research Council (CSIC) scientific publications on Altmetric

Información, Cultura y Sociedad
La influencia mediática de la investigación científica, entendida como aquella que llega a la sociedad a través de las menciones de artículos científicos en los medios de comunicación, se analiza en el área de Humanidades y Ciencias Sociales (HCS), con ...
Daniela De Filippo, Borja González-Albo
doaj   +1 more source