Results 61 to 70 of about 6,128,347 (311)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Who You Gonna Call? Insights from the ECJ’s Case C-551/21 on the Signature of International Agreements

European Papers
(Series Information) European Papers - A Journal on Law and Integration, 2024 9(1), 121-129 | European Forum Insight of 18 June 2024 | (Table of Contents) I. Introduction. - II. Signature of international agreements: the (in)consistent practice.
Felipe Tomazini de Souza
doaj   +1 more source

El municipio constitucional en la España de 1812

Revista de Derecho Político, 2012
El artículo tiene por objeto el estudio de la institución municipal en la Constitución de Cádiz de 1812. Principia la exposición analizando el modelo de municipio propugnado por gobierno bonapartista caracterizado por el acendrado centralismo contrario a
Enrique Orduña Rebollo
doaj   +1 more source

The Legitimacy and Moral Authority of the National News Council (USA) [PDF]

, 2008
As an institution designed to resolve disputes between the public and the American news media and to assess the ethical standards of the mainstream media, the National News Council (1973-84) was, at least in the USA, a ground-breaking institution.
Ugland, Erik
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Contributions of ʿUrf (Custom) to Politics and Political Structure with a View to Shia Jurisprudence (From the Perspective of Shia Jurists) [PDF]

Journal of Islamic Political Studies
Custom or customary practice (ʿurf) is an important phenomenon in Shiite jurisprudence, which became more intertwined with its discourse after the dominance of the Usuli scholars over the Akhbari tradition.
Omid Khalili-Mehr, Majid Tavasoli Roknabadi, Ali Shirkhani   +2 more
doaj   +1 more source

Benefits and barriers to engagement of mental health caregivers in advisory roles: Results from a cross‐sectional survey

Health Science Reports, 2023
Background and Aims Mental health institutions and community organizations have had difficulty recruiting patients and caregivers onto their Patient, Family, and Community Advisory Committees (PFACs).
Cynthia Clark, Alexis Dorland, Natalia Jaworska, Robyn J. McQuaid, Michèle Langlois, Florence Dzierszinski   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

On the role of infiltration and exfiltration in swash zone boundary layer dynamics [PDF]

, 2015
Funded by Mexican National Council of Science and Technology (CoNACyT) . Grant Number: 490080 Fulbright-Garcia Robles grant Instituto de Ingeniería UNAM International Collaborative Research project University of Delaware DGAPA UNAM National Science ...
Pintado-Pati, Jose Carlos, Pokrajac, Dubravka, Puleo, Jack A., Torres-Freyermuth, Alec   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source