Results 41 to 50 of about 93,355,549 (214)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Transition in career counselling practice : what can solution-oriented counselling offer?
, 2002 The counselling profession has been challenged to respond to the demands of an increasingly complex and rapidly changing world. In personal counselling, the response has seen the increased adoption of principles, processes and approaches informed by the ...
Adams, Mandy, Lim, Ros, McMahon, Mary
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Career counselors’ experiential reflections on early recollections in career construction counseling
The Career Development Quarterly, 2023 AbstractMany studies validate career construction counseling (CCC); however, counselors’ experiences of using early recollections (ERs) in CCC have garnered little research attention. Preliminary research among career counselors in Norway has revealed skepticism about using ERs, owing to aspects such as associations with therapy.
openaire +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Life themes in career counselling
, 2011 This chapter addresses life themes in career counselling. Life themes are conceptualised as significant dimensions of career, subjectively and objectively understood.
McIlveen, Peter
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Using qualitative assessment in career counselling
, 2002 Advancements in conceptualisations about career and career development and irreversible changes in the world of work have necessitated that career counsellors reflect on their practice in order that it keeps pace and maintains relevancy.Fundamental to ...
McMahon, Mary L. +3 more
core +1 more source