Results 31 to 40 of about 43,242 (248)

The Paleo-Orientations of Northwestern Borneo and Adjacent South China Sea Basins

Indonesian Journal on Geoscience, 2014
DOI: 10.17014/ijog.v7i2.136Limited paleomagnetic data from West Kalimantan and southwestern Sarawak appear to indicate counter-clockwise (CCW) rotation of over 50 degrees during Cenozoic.
H. D. Tjia
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Flagellar polymorphism-dependent bacterial swimming motility in a structured environment

Biophysics and Physicobiology, 2023
Most motile bacteria use supramolecular motility machinery called bacterial flagellum, which converts the chemical energy gained from ion flux into mechanical rotation.
Yoshiaki Kinosita, Yoshiyuki Sowa
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dichloridobis[3-methoxymethyl-4-phenyl-5-(2-pyridyl)-4H-1,2,4-triazole-κ2N1,N5]chromium(III) chloride

Acta Crystallographica Section E, 2011
In the title complex, [CrCl2(C15H14N4O)2]Cl, the CrIII atom is located on a twofold rotation axis and is coordinated by two N,N′-bidentate triazole derivatives and two chloride ions in a distorted octahedral CrN2N′2Cl2 geometry.
Xiaofei Jin, Zuoxiang Wang, Shouping Cao
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Effects of neutral beam injection on tearing mode stability: insights from hybrid simulations

Nuclear Fusion
In tokamak plasmas, tangential neutral beam injection (NBI) produces (a large fraction of) circulating energetic ions (CEIs) and induces plasma toroidal rotation, both of which play an important role in the stability of tearing mode (TM).
Sizhe Duan, Xiang Zhu, Huishan Cai
doaj   +1 more source

Heat transfer enhancement of a channel flow by rotation circular cylinder

Nihon Kikai Gakkai ronbunshu, 2015
Heat transfer measurement has been done for a low speed water channel with an insertion of rotation circular cylinder in order to find an effective way to achieve high heat transfer enhancement by dynamic flow control method.
Norihiro TAKAHASHI, Eisaku MORITA, Yuhei INOUE, Guannan XI, Kyoji INAOKA, Mamoru SENDA   +5 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source