Results 91 to 100 of about 6,501,219 (332)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Local Unit Invariance, Back-Reacting Tractors and the Cosmological Constant Problem

, 2010
When physics is expressed in a way that is independent of local choices of unit systems, Riemannian geometry is replaced by conformal geometry. Moreover masses become geometric, appearing as Weyl weights of tractors (conformal multiplets of fields ...
A Waldron, Antoniadis I, Bailey T N, Bars I, Bianchi M, Carroll S M, Distler J, Fefferman C, Freedman D Z, Freedman D Z, Girardello L, Gover A R, Gover A R, Henningson M, Higuchi A, J de Boer, Maldacena J M, N Arkani-Hamed, O Corradini, P van Nieuwenhuizen, P van Nieuwenhuizen, Polchinski J, Polyakov A M, Polyakov A M, R Bonezzi, Shaukat A, Thomas T Y, Weinberg S, Weyl H, Witten E, Witten E, Zumino B   +31 more
core   +1 more source

Elastic Stress Coupling Between Supraglacial Lakes

Journal of Geophysical Research: Earth Surface
AbstractSupraglacial lakes have been observed to drain within hours of each other, leading to the hypothesis that stress transmission following one drainage may be sufficient to induce hydro‐fracture‐driven drainages of other nearby lakes. However, available observations characterizing drainage‐induced stress perturbations have been insufficient to ...
Laura A. Stevens, Sarah B. Das, Mark D. Behn, Jeffrey J. McGuire, Ching‐Yao Lai, Ian Joughin, Stacy Larochelle, Meredith Nettles   +7 more
openaire   +2 more sources

Two-Phase Couette Flow of Couple Stress Fluid with Temperature Dependent Viscosity Thermally Affected by Magnetized Moving Surface

Symmetry, 2019
The Couette–Poiseuille flow of couple stress fluid with magnetic field between two parallel plates was investigated. The flow was driven due to axial pressure gradient and uniform motion of the upper plate.
R. Ellahi, A. Zeeshan, F. Hussain, T. Abbas   +3 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Surface roughness effect on thermohydrodynamic analysis of journal bearings lubricated with couple stress fluids

Nonlinear Engineering, 2019
The paper presents, surface roughness effect for thermo-hydrodynamic analysis of journal bearings extended to couple stress lubricants with high polymer additives. A modified energy equation is simultaneously solved with heat transfer equation as well as
Awati Vishwanath B., Kengangutti Ashwini
doaj   +1 more source

Coupled stress-diffusion: Case II

Journal of the Mechanics and Physics of Solids, 1993
The problem of a molecular deformation in a polymeric solid is considered using the global balance principles and micromechanical considerations. A complete set of coupled governing balance equations and constitutive laws is given. An example of the initial-boundary value problem is presented to demonstrate that the qualitative features of diffusion ...
Govindjee, Sanjay, Simo, Juan C.
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Influence of couple stress and magnetic fluid on the performance of step slider bearing

International Journal of Applied Mechanics and Engineering
This theoretical investigation delves into the performance of step slider bearings, considering the influence of couple stress and magnetic fluid as the lubricating medium.
Dipali K. Chauhan, JIMIT R. PATEL, G.M. Deheri   +2 more
doaj   +1 more source

Restructuring of colloidal aggregates in shear flow: Coupling interparticle contact models with Stokesian dynamics

, 2012
A method to couple interparticle contact models with Stokesian dynamics (SD) is introduced to simulate colloidal aggregates under flow conditions.
A.A. Potanin, C. Dominik, C. Dominik, D. Kadau, D. Zhang, D.F. Bagster, D.R. Foss, F.A. Gilabert, G. Bossis, G.B. Jeffery, Günter K. Auernhammer, H. Sakaguchi, Heiko Briesen, J. Tomas, J.-Y. Delenne, J.F. Brady, J.P. Pantina, K. Higashitani, K. Ichiki, K. Iwashita, K. Wada, L. Durlofsky, L.-O. Heim, M. Lattuada, M. Smoluchowski, M. Zeidan, M.J. Jiang, M.L. Eggersdorfer, M.Y. Lin, P.J. Lu, P.M. Adler, R. Botet, R. Buscall, R. Buscall, R. Seto, R. Seto, R. Wessel, R.C. Sonntag, Robert Botet, Ryohei Seto, S. Harada, S. Luding, T.N. Phung, V. Becker, V. Becker, V. Becker, Y.M. Harshe, Y.M. Harshe   +47 more
core   +1 more source