Results 101 to 110 of about 6,501,219 (332)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Effect of Magnetohydrodynamic Couple Stresses on Dynamic Characteristics of Exponential Slider Bearing

Tribology in Industry, 2017
The effect of couple stresses on static and dynamic characteristics of exponential slider bearing in the presence of magnetic field considering squeeze action is theoretically analyzed in this paper.
N.B. Naduvinamani, A. Siddangouda, P. Siddharam   +2 more
doaj  

Effect of spin slip conditions on Couette-Poiseuille flow of couple stress fluid between parallel plates

Applied and Computational Mechanics
In the current paper, we investigate the effect of spin slip conditions for the Couette-Poiseuille flow of a couple stress fluid between two parallel plates.
Nishad S., Madasu K. P.
doaj   +1 more source

Couple stress theory for solids

International Journal of Solids and Structures, 2011
AbstractBy relying on the definition of admissible boundary conditions, the principle of virtual work and some kinematical considerations, we establish the skew-symmetric character of the couple-stress tensor in size-dependent continuum representations of matter.
Hadjesfandiari, Ali R., Dargush, Gary F.
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Analysis of the Lubrication Performance of Bearing with Non-Newtonian Magnetic Fluids with Considering Stress Couple Effect

Jixie chuandong, 2017
Based on the Reynolds equation considering the stress couple and magnetic field,the numerical analysis of the non-Newtonian magnetic fluid lubricated bearing is carried out.
Chen Chao, Zhang Hong
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Impact of Spin Slip Conditions on the Axisymmetric Rotation of a Spherical Particle in a Couple Stress Fluid Within a Cavity

Engineering Transactions
This paper investigates the effect of spin slip condition on the flow of a couple stress fluid between two concentric spheres. The spherical particles rotate about the z-axis with different angular velocities  and  under the assumption of low Reynolds ...
Shekhar NISHAD, Krishna Prasad MADASU
doaj   +1 more source