Results 91 to 100 of about 2,450,147 (304)

Efficiency Optimization of a 7 kW EV Charger Based on a Coupled Inductor Design

World Electric Vehicle Journal
Electric vehicle (EV) chargers play an important role in the popularity of electric vehicles. In order to improve the efficiency of EV chargers, this paper replaces the discrete inductors in an interleaved Boost PFC topology with a coupled inductor ...
Xie Ning, Duotong Yang, Xiaohui Cao, Zhenglei Wang   +3 more
doaj   +1 more source

Benefits of the CI-CCS converter

The Journal of Engineering, 2019
An enhanced DC–DC converter is proposed in this paper, based on the combination of the Cuk converter and single-ended primary-inductor converter (SEPIC).
Kumaran S. Nathan, Saikat S. Ghosh, Saikat S. Ghosh, Prabhat R. Tripathi, Yam P. Siwakoti, Timothy J. Flack, Xinru Li, Teng Long   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

A Novel Photo-Voltaic Low-Power Boost Converter With Double Coupled Inductors

IEEE Access
Solar power has recently been the focus of extensive research. Harvesting power during overcast conditions remains a significant challenge for solar energy systems. To address this, converters must achieve a higher voltage gain.
Maziar Rastmanesh
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Multiport/Multiphase DC/DC Converter with Coupled Inductors for Hybrid Energy Storage Systems Suitable for Aircraft Applications

Machines
This paper proposes a low weight hybrid battery–supercapacitor energy storage system interfaced with bidirectional DC/DC converters with high power/current capability for aircraft applications.
Abdullahi Abubakar, Christian Klumpner, Patrick Wheeler   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

An Advanced High-Gain DC–DC Converter With Zero-Voltage Switching

IEEE Access
This paper presents an interleaved high-step-up DC-DC converter with high voltage gain. The proposed converter introduces an innovative configuration of coupled inductors and series capacitors, providing multiple operational benefits without auxiliary ...
Zeynab Jalili Yegane, Amin Asghari
doaj   +1 more source