Results 101 to 110 of about 1,457,084 (256)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

New High Step-Up Two-Stage DC-DC Converter With Two Coupled Inductors and Switch Capacitor

IEEE Open Journal of Power Electronics
This paper presents a high-step-up DC-DC converter suitable for low-voltage source applications, such as renewable energy systems. The proposed topology integrates a two-stage structure, two coupled inductors with dual windings, and a voltage lift ...
Iman Soltani, Saeed Sharifi Jeze, Gholam-Reza Molaeimanesh, Hani Vahedi   +3 more
doaj   +1 more source

A Current-Doubler Rectifier with Coupled Inductors for High Step-Down Applications

, 2014
[[abstract]]In this paper, a current-doubler rectifier with coupled inductors for high step-down applications is proposed. The proposed current-doubler rectifier includes two sets of coupled inductors, which can extend duty ratio to reduce the pea ...
T.-F. Wu;C.-T. Tsai;C.-L. Shen;Y.-M. Chen
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Very high step‐down coupled inductor two‐phase buck converter with single magnetic element and inherent clamp voltage capability

IET Power Electronics
This paper proposed a new two‐phase high step‐down DC–DC converter is proposed. This converter is derived from the two‐phase series‐capacitor converter. The proposed converter replaces the series capacitor with a new structure that integrates Valley‐Fill
Ahmad Ghamsari Esfahani, Ehsan Adib
doaj   +1 more source

Multiphase voltage regulator having coupled inductors with reduced winding resistance

, 2007
A multiple phase buck converter or boost converter, or buck-boost converter has an inductor in each phase. The inductors are inversely coupled. In a first embodiment, the converter includes a toroidal magnetic core with inductors extending under and over

core  

Coupled inductors design of the bidirectional non-inverting buck-boost converter for high-voltage applications

, 2020
This work analyses the effects on the efficiency of the winding-to-winding capacitance of the coupled-inductor of the bidirectional non-inverting buck-boost converter in high-voltage applications.
Gonzalez-Castano, Catalina; Restrepo, Carlos; Giral, Roberto; Garcia-Amoros, Jordi; Vidal-Idiarte, Enric; Calvente, Javier;
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Interleaved ZVS DC‐DC converter with ultrahigh step‐down and flexible gain

IET Power Electronics
This paper proposes a novel non‐isolated ultrahigh step‐down interleaved DC‐DC converter with an extremely extended duty cycle based on the series capacitor and coupled‐inductor techniques. The proposed converter utilizes a three‐winding coupled inductor
Wahid Eskandary, Mohammad Monfared, Ali Nikbahar, Ahmad Mahdave   +3 more
doaj   +1 more source