Results 41 to 50 of about 1,086,052 (297)

The impact of resolution on the adjustment and decadal variability of the Atlantic Meridional Overturning Circulation in a coupled climate model [PDF]

, 2012
Variations in the Atlantic Meridional Overturning Circulation (MOC) exert an important influence on climate, particularly on decadal time scales. Simulation of the MOC in coupled climate models is compromised, to a degree that is unknown, by their lack ...
Hodson, Daniel L. R., Sutton, Rowan T.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Quality and Testing of Red Pepper Soft Picking Manipulator Based on RD-DEM Coupling

Agriculture
Due to a shortage of labor, the harvesting of fruits and vegetables faces significant challenges. Soft robotic hands, adaptable to variable environments due to their high-curvature bending and twisting, have garnered widespread attention and usage ...
Hanqi Zhao, Jian Wang, Yang Liu, Zhifan Chen, Jingqi Wang, Lin Chen   +5 more
doaj   +1 more source

Co-Simulation of Algebraically Coupled Dynamic Subsystems [PDF]

Dynamic Systems and Control, 2001
Abstract This paper analyzes the problem of Co-Simulation. The term Co-Simulation is used to describe a large dynamic system that is simulated by running a group of independently coded subsystem simulators. Very commonly, the Co-Simulation of subsystems faces incompatible boundary conditions, i.e., causal conflicts.
Bei Gu, H. Harry Asada
openaire   +1 more source

Coupled Geothermal Energy Simulations

Journal of Physics: Conference Series, 2022
Abstract This paper presents the numerical solution of thermal field of a set of geothermal coaxial probes coupled with the surrounding soil. These probes, used for the excavation of Naples underground’s tunnels with the artificial ground freezing technique, are converted for the heat transfer fluid transport for a geothermal plant.
armando di meglio, Massarotti N., Mauro A., Trombetta V.   +3 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Applying uncertainty considerations to energy conservation equations [PDF]

, 2007
When applying computer simulation tools in practice uncertainties abound, for example in material properties and boundary conditions. To facilitate the quantification of the effects of uncertainties, the differential, factorial and Monte Carlo methods ...
Clarke, I.A. Macdonald, J.A. Clarke, Macdonald, Moore, Neumaier   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Simulation of high-spin Heisenberg models in coupled cavities

, 2008
We propose a scheme to realize the Heisenberg model of any spin in an arbitrary array of coupled cavities. Our scheme is based on a fixed number of atoms confined in each cavity and collectively applied constant laser fields, and is in a regime where ...
Dimitris G. Angelakis, F. D. M. Haldane, Jaeyoon Cho, Sougato Bose   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source