Results 61 to 70 of about 4,152,141 (291)

Time domain coupled simulation of machine tool dynamic behaviour and cutting force based on voxel simulator of machining operation

Nihon Kikai Gakkai ronbunshu, 2017
It is known that the cutting force excites the structural vibration of machine tool. In addition, cutting force acts on feed and spindle drive system as a force disturbance, and feed speed and spindle speed are changed.
Shin NOGUCHI, Isamu NISHIDA, Ryuta SATO, Keiichi SHIRASE   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysis of Breaking and Separating Characteristics of Potato–Soil Aggregates Based on the New Type of Swing Separation Sieve

Agronomy
In response to the significant challenge posed by the trade-off between the efficiency of separating potato soil and minimizing potato peel damage in the 4SW-170 potato excavator, this study focused on enhancing the design of the swing separation sieve ...
Shengshi Xie, Yufeng Zhang, Junru Li, Fei Liu   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A simulation of mass transport across series arrays of membranes with chemical-reaction-coupled solute flow

, 1988
This paper presents the results of a simulation of water and solute transport across a series array of several membranes, using a model which allows the treatment of arrays of n membranes with “active” (chemical reaction coupled) solute transport ...
G. Monticelli, F. C. Celentano, F. Cottini   +2 more
core   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Efficient simulation of interconnects in high-speed circuits [PDF]

, 2003
The paper presents an efficient approach for the simulation of interconnects in high-speed circuits based on measured data or simulated EM data. The approach involves forming an initial transmission-line model based on a resonant approach introduced by ...
Condon, Marissa, Dautbegovic, Emira
core   +2 more sources

Design and Simulation of Internal Planetary Wheel Plunger-Type Ring Molding Machine for Biomass Pellets

BioResources
Key components of the existing external meshing dorsal spine plunger-type molding machine were modeled in three dimensions, and the fatigue life analysis of the molding machine spindle was carried out by using Ansys software.
Xuehong De, Bowen Zhang, Jingyan Zhao, Wenbin Guo, Jianchao Zhang, Jianwen Kang, Haoming Li   +6 more
doaj   +2 more sources

Simulation and Optimization Experiment of Seven-Link Planting Mechanism Based on Discrete Element Method and Multibody Dynamics (DEM–MBD) Coupling

AgriEngineering
To address issues in traditional vegetable transplanter planting mechanisms such as poor hole-forming quality and low seedling uprightness, a seven-bar linkage planting mechanism with posture compensation of seedling entering soil was designed.
Zhichao Cui, Jingjing Fu, Yundong Wang, Yating Yang, Jingling Song, Kangping Lu, Xingchang Huang, Hongli Liang, Binxing Xu, Weisong Zhao, Yongsheng Chen, Chunsong Guan, Chenghao Zhang   +12 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source