Results 71 to 80 of about 4,152,141 (291)

Coupled Hydraulic Fracture and Proppant Transport Simulation

Energies, 2020
This paper focuses on the study of proppant transport mechanisms in fractures during frac-packing operation. A multi-module, numerical proppant, reservoir and geomechanics simulator has been developed, which improves the current numerical modeling ...
Morteza Roostaei, Alireza Nouri, Vahidoddin Fattahpour, Dave Chan   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Time-Domain Simulation of Mixed Nonlinear Magnetic and Electronic Systems

, 2001
This paper describes a technique for the simulation of complex magnetic systems intimately connected to any necessary drive electronics. The system is split into two Kirchhoffian domains, one magnetic and one electric.
KG, Nichols, JN, Ross, AD, Brown
core   +1 more source

Design and Experiment of Air-Suction Roller-Type Minituber Seed-Metering Device Based on CFD-DEM

Agriculture
Aiming at the problems of the high multiple- and missed-seeding index and low operation efficiency of current mechanical potato seed-meters in minituber sowing, this study designed an air-suction roller-type minituber seed-metering device for minitubers (
Jicheng Li, Haiqin Ma, Yuxuan Chen, Xiaoxin Zhu, Yu Qi, Qiang Gao, Jinqing Lyu   +6 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Motion Analysis of International Energy Agency Wind 15 MW Floating Offshore Wind Turbine under Extreme Conditions

Journal of Marine Science and Engineering
In recent years, ultra-large-scale offshore wind turbines have attracted widespread attention. However, accurately evaluating the motion responses of offshore wind turbines under extreme conditions, especially for semisubmersible floating off-shore wind ...
Zengliang Chang, Yueming Zheng, Meng Qu, Xingguo Gao, Xiaojie Tian, Guijie Liu   +5 more
doaj   +1 more source

Coupled Simulations in Plasma Physics with the Integrated Plasma Simulator Platform

Procedia Computer Science, 2015
AbstractSimulations of fusion plasma obtained in a Tokamak device can involve a wide range of physics phenomena occurring at different scales. Programming such a simulation is challenging and tends to increase the complexity of the code and its maintenance.
Olivier Hoenen, David Coster, S. Petruczynik, Marcin Plóciennik   +3 more
openaire   +2 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source