Results 91 to 100 of about 3,054,537 (278)

Two Loop Computation of a Running Coupling in Lattice Yang-Mills Theory

open access: yes, 1995
We compute the two loop coefficient in the relation between the lattice bare coupling and the running coupling defined through the Schroedinger functional for the case of pure SU(2) gauge theory.
de Divitiis   +14 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Stability of mud-water interface under long surface waves

open access: yesAIP Advances, 2019
Fluid mud often exists in coastal areas with an interface separating it from its upper water layer. When a surface wave propagates over a bed covered with water and fluid mud, it will cause an interfacial wave of the mud-water interface, which damps the ...
Jiebin Liu, Jifu Zhou
doaj   +1 more source

Coupling Poisson and Jacobi structures on foliated manifolds

open access: yes, 2004
Let M be a differentiable manifold endowed with a foliation F. A Poisson structure P on M is F-coupling if the image of the annihilator of TF by the sharp-morphism defined by P is a normal bundle of the foliation F.
Dazord P.   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Understanding of temperature and cooling effectiveness sensitivity of a film-cooled vane under coolant inlet temperature effect: A case study

open access: yesCase Studies in Thermal Engineering, 2019
This work presents a case study of the relationship between temperature and cooling effectiveness of a film-cooled vane under effect of coolant inlet temperature in two aspects based on the actual and base coolant inlet temperatures.
Prasert Prapamonthon   +3 more
doaj   +1 more source

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