Results 91 to 100 of about 312,052 (282)

Spatio-temporal characteristics and coupling coordination relationship between industrial green water efficiency and science and technology innovation: A case study in China

Ecological Indicators
To achieve the objective of high-quality development, an in-depth examination of the coupling coordination relationship between industrial green water and science and technology (S&T) innovation is essential.
Fuhua Sun, Jiayi Guo, Xin Huang, Zelong Shang, Bu Jin   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Research on the coupling measurement of medical education and health resource allocation under the background of healthy China

BMC Medical Education
Objective To analyze the coupling and coordination level of medical education and health resource allocation in China, and to provide scientific basis for promoting the high-quality development of medical education and the efficient allocation of health ...
Chen Jieting, Zhu Yan, Song Zhilong, Li Siyuan, Wu Xiangwei   +4 more
doaj   +1 more source

Coordinating Loosely-Coupled Work in Construction Inspection Activities

Group Decision and Negotiation, 2010
Inspections represent key activities in construction projects. They allow coordinating the work of the main contractor and the subcontracted companies participating in the project. Today the inspection activities and the coordination process are done using information recorded into paper-based blueprints.
Ochoa Delorenzi, Sergio, Bravo, Gabriel, Pino Urtubia, José, Rodríguez Covili, Juan   +3 more
openaire   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Phase diagram of four-dimensional dynamical triangulations with a boundary [PDF]

, 2000
We report on simulations of DT simplicial gravity for manifolds with the topology of the 4-disk. We find evidence for four phases in a two-dimensional parameter space. In two of these the boundary plays no dynamical role and the geometries are equivalent
Adi, Ambjorn, Ambjorn, Bialas, Catterall, Catterall, Catterall, de Bakker, Hartle, Metropolis, Simeon Warner, Simon Catterall, Warner   +12 more
core   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

4f and 5d levels of Ce3+ in D2 eightfold oxygen coordination

, 2012
The effects on the 4f and 5d levels of Ce3+ of its first coordination shell geometry in Ce-doped oxides with a D2 8-fold site, like garnets, are studied with embedded cluster, wave function based ab initio methods.
Barandiaran, Zoila, Seijo, Luis
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The coupling coordination relationship and promotion path of green economic efficiency and urban land development intensity: based on the case study of 283 prefecture-level cities

Frontiers in Sustainable Food Systems
The coordination and interaction of green economy efficiency (GEE) and urban land development intensity (ULDI) constitute a critical pathway toward achieving sustainable urban development.
Jiao Hou, Jiao Hou, Xupeng Zhang, Zhenhui Qi, Zhu Mei, Xinhai Lu, Mengna Li, Xinxue Cheng, ManJing Chen, Xiangyu Fan, Xiangyu Fan   +10 more
doaj   +1 more source