Results 81 to 90 of about 194,657 (294)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Quantum Engineering of Spin and Anisotropy in Magnetic Molecular Junctions

, 2015
Single molecule magnets and single spin centers can be individually addressed when coupled to contacts forming an electrical junction. In order to control and engineer the magnetism of quantum devices, it is necessary to quantify how the structural and ...
Brovko, Oleg, Herden, Tobias, Jacobson, Peter, Kern, Klaus, Laskin, Gennadii, Muenks, Matthias, Stepanyuk, Valeri, Ternes, Markus   +7 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Locational-based Coupling of Electricity Markets: Benefits from Coordinating Unit Commitment and Balancing Markets [PDF]

, 2010
We formulate a series of stochastic models for committing and dispatching electric generators subject to transmission limits. The models are used to estimate the benefits of electricity locational marginal pricing (LMP) that arise from better ...
Hobbs, B.F., Weijde, A.H. van der
core   +4 more sources

Coupling Analysis of Urban Land Use Benefits: A Case Study of Xiamen City

Land, 2020
The high coupling coordination of urban land use benefits is a significant factor for urbanization and sustainable urban development. This study, based on the statistical data from 2002 to 2017 of Xiamen City, constructs an index system that includes ...
Xuanming Ji, Kun Wang, Tao Ji, Yihua Zhang, Kun Wang   +4 more
doaj   +1 more source

Coupling coordination degree of infrastructure and energy productivity: spatial analysis for China

Spatial Economic Analysis
Under resource constraints, exploring the impact of infrastructure transformation on energy productivity (EP) holds significant importance. This study examines the impact of coupled coordination of infrastructure (CC) on EP using inter-provincial data from China and conducts a scenario analysis and cross-country comparisons.
Yuan Ma, Zi-ran Zhang, Yu-ling Yang
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Spatio-Temporal Evolution and Influencing Factors of Supply–Demand Coupling and Coordination in Civil Aviation Passenger Transport

Applied Sciences
The interaction between supply and demand of civil aviation passenger transport serves as an important reference for airport planning, transportation structure optimization and dynamic matching of supply and demand. Based on the panel data of 31 province-
Yanling Yang, Minghua Hu, Jianan Yin, Wei Wu   +3 more
doaj   +1 more source

Spin wave stiffness and exchange stiffness of doped permalloy via ab-initio calculation

, 2019
The way doping affects the spin wave stiffness and the exchange stiffness of permalloy (Py) is investigated via ab-initio calculations, using the Korringa-Kohn-Rostoker (KKR) Green function formalism.
Ebert, Hubert, Mankovsky, Sergey, Sipr, Ondrej   +2 more
core   +1 more source