Linguistic and Cognitive Ability of Children Before Five Years Old on Their Effort to Communicate Action [PDF]
, 2017 We here described on the ability of children before their old five years old. They have a special power in learning their life to able to do something. Of course, they have a difficult thing regarding how to communicate each other.
Graw, N. J. (Norra) +1 more
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Activités, 2016 This article is an empirical contribution to the field of educational technology but also — and above all — a methodological contribution to the analysis of the activities enacted in this field.
Simon Flandin, Marine Auby, Luc Ria
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
How can I produce a digital video artefact to facilitate greater understanding among youth workers of their own learning-to-learn competence? [PDF]
, 2011 In Ireland, youth work is delivered largely in marginalised communities and through non-formal and informal learning methods. Youth workers operate in small isolated organisations without many of the resources and structures to improve practice that is ...
Crossan, Shane
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The community engagement course and action network: strengthening community and academic research partnerships to advance health equity. [PDF]
Front Public Health, 2023 Akintobi TH +18 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Designing and piloting a bridging programme between the Additional Diploma Awards: provider final report [PDF]
A report of the pilot and evaluation of a bridging course between the Additional Diploma ESOL and Literacy awards funded by LSIS as an action ...
Ade-Ojo, Gordon, LSIS
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Preparing Higher Education Tutors for Delivering Online Courses [PDF]
, 2015 This paper identifies that academic staff need to be suitably prepared to deliver wholly online courses, and outlines the steps taken towards achieving this, at one Higher Education institution in the UK. E-learning, whether partially (blended) or wholly
Allen, Jessica +3 more
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