Results 81 to 90 of about 4,509,075 (305)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Connaissances et cours d’expérience
Revue d'anthropologie des connaissances, 2009 The method of “course of action” permits a global study of learners and the dynamic of their knowledge in education and training. It makes possible description made by the individuals that talk about their experience.
Gilles Dieumegard
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Inadvertent - Ars accidentalis [PDF]
, 2008 Even though art is the product of an intentional act of fabrication, the serendipitous spill of an ink or paint, the unforeseen slip of a pen or brush, sudden shake of a camera in the analog realm have the potential of generating an unconscious lead in ...
Germen, Murat
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Developing mathematical thinking in the primary classroom: liberating students and teachers as learners of mathematics [PDF]
, 2015 This paper reports on a research study conducted with a group of practising primary school teachers (n = 24) in North East Scotland during 2011–2012. The teachers were all participants in a newly developed Masters course that had been designed with the ...
Alison Hudson +16 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Case studies to enhance online student evaluation: Central Queensland University – The big red button [PDF]
, 2015 Student feedback is imperative to the improvement of courses and teaching. As stated by Harvey, “to make an effective contribution to internal improvement processes, views of students need to be integrated into a regular and continuous cycle of analysis,
Fleming, Julie +7 more
core +1 more source
, 2018 This was to be a talk given before the Portland State University, Impact Summit Pitch Fest in Portland, Oregon in early February 2018. Unfortunately, it was not picked. I fear the reason may be the subject matter: a future living with early warning systems, hardening human settlements, and giving survival options to people who want to stay in place as ...
openaire +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source