Results 191 to 200 of about 1,131,860 (291)

The mRNA covalent modification dihydrouridine regulates transcript turnover and photosynthetic capacity during plant abiotic stress. [PDF]

Plant Cell
Yu L, Melandri G, Dittrich ACN, Calleja S, Ganguly DR, Palos K, Brewer EK, Fischer H, Rozzi B, Srinivasan A, Obata T, AbdElgawad H, Beemster GTS, Henderson R, Garcia C, Zhang X, Stern D, Eveland A, Lyons E, Arnold AE, Skirycz A, Schroeder SJ, Gregory BD, Pauli D, Nelson ADL.   +24 more
europepmc   +1 more source

Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency. [PDF]

J Chem Inf Model, 2022
Galvani F, Scalvini L, Rivara S, Lodola A, Mor M.   +4 more
europepmc   +1 more source

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Omeprazole activation of CD4+ and CD8+ T-cells through off-target covalent modification of cellular proteins. [PDF]

Toxicol Sci
Grice S, Albashtawy S, Wells G, Hering L, Adair K, Sarsby J, Brownridge P, Ford M, Lloyd R, Hampson L, Wagner A, Sun Y, Liu H, Hammond S, Meng X, Zhang F, Naisbitt D.   +16 more
europepmc   +1 more source

Protein‐Polymer Dynamic Hydrogels Utilizing Native Ligand Binding for Injectable Therapeutic Delivery and 3D Printing

Advanced Healthcare Materials, EarlyView.
Dynamic nanocolloidal hydrogels were synthesized via the co‐assembly of ligand‐modified spheroidal hyperbranched poly(glycerol) (HPG) and soluble albumin nanoparticles (SANs). Co‐assembly occurred through self‐association of the HPG, as well as its interaction with SANs via native ligand binding.
S. Cem Millik, Yonghui Wang, Kefan Song, Jessica M. Snyder, LeAnn Le, Lauren G. Brown, Shanny Hsuan Kuo, Ashleigh B. Theberge, Suzie H. Pun, Alshakim Nelson   +9 more
wiley   +1 more source

A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates. [PDF]

J Am Chem Soc
Chen Z, Liu L, Cattin J, Knowles TPJ, Bernardes GJL.   +4 more
europepmc   +1 more source

Rational Control of Antibody Orientation for Enhancing Sensitivity and Specificity in Lateral Flow Immunoassays With Clinical Validation

Advanced Healthcare Materials, EarlyView.
Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang, Shunmuga Nathan Shunmuga Nainar, Bing‐Han Zhuang, Shun‐Mao Yang, Hong‐Cheu Lin, Yang‐Hsiang Chan   +5 more
wiley   +1 more source

Covalent modification of Keap1 Cys489 by NU6300 activates Nrf2 signaling and suppresses NLRP3 inflammasome-mediated pyroptosis. [PDF]

J Pharm Anal
Jiang X, Zheng H, Zhang X, Tang M, Peng J, Cai X, Su K, Zhang R, Ye N, Lin L, Ma R, Shen C, Wu W, Ye H.   +13 more
europepmc   +1 more source

Production of C, N Alternating 2D Materials Using Covalent Modification and Their Electroluminescence Performance. [PDF]

Small Sci, 2021
Park S, Kim YH, Kang S, Lim D, Park J, Jang D, Choi S, Kim J, Han S, Lee TW, Park S.   +10 more
europepmc   +1 more source

The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3‐Dimensional Hydrogels

Advanced Healthcare Materials, EarlyView.
The role of viscoelasticity in the invasion of heterogeneous glioblastoma stem cells (GSCs) was investigated with GSCs categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive using viscoelastic biomimetic hyaluronan‐oxime hydrogels.
Nicole J. Blaine, Arianna Skirzynska, Allysia A. Chin, Julie Audet, Molly S. Shoichet   +4 more
wiley   +1 more source