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Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013Multimeric globins (e.g., hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric globins (e.g., myoglobin; Mb) usually are assumed to be non-allosteric. However, the modulation of the functional properties of monomeric globins by non-covalent (or allosteric) and covalent modifications casts doubts on this general ...
Ascenzi, P +10 more
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Covalent modification and metabolic control analysis
European Journal of Biochemistry, 1990A study of the sensitivity properties of metabolic systems containing covalently modifiable enzymes and cascades has been carried out with the aid of metabolic control analysis. We have considered how the theorems of metabolic control analysis must be modified to take into account covalently modifiable enzymes, and have used these results to ...
J R, Small, D A, Fell
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Inheritance of a covalent histone modification
Science, 2015Epigenetics Genomic DNA is the repository of all genetic information and is packaged into chromatin. Chromatin is also a repository of regulatory information in the form of covalent marks added to the histones that package the DNA. These marks can determine tissue- and organ-specific gene expression patterns, which must be transmitted to daughter cells
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Enhancement of anticancer potential of polyphenols by covalent modifications
Biochemical Pharmacology, 2016As evidenced by a growing number of respective clinical trials, a promising and increasingly valued approach to cancer prevention is chemoprevention which is based on using synthetic, semisynthetic, or natural compounds with the aim of preventing, delaying, arresting, or reversing carcinogenesis.
Urszula, Lewandowska +2 more
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Improvement by Covalent and Noncovalent Modification
1978As mentioned in earlier Chapters, cyclodextrins exhibit many interesting features such as rate effects, stereospecificity, enantiomeric specificity, etc., in organic reactions. However, there is one serious hortcoming of cyclodextrins as catalysts.
Myron L. Bender, Makoto Komiyama
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Tyrosinase enhances the covalent modification of DNA by dopamine
Molecular Brain Research, 1996Dopamine-induced DNA damage was studied in vitro in the presence of the enzyme tyrosinase. Dopamine auto-oxidizes to form dopamine quinone, a reactive molecule which spontaneously decomposes to form additional reactive species that can modify cellular macromolecules.
A H, Stokes +4 more
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Covalent modification of nuclear proteins during aging
1975An in vitro assay system has been established to study acetylation and phosphorylation of nuclear proteins from isolated nuclei. Phosphorylation of neclear proteins reached a peak within 5 min while maximum acetylation occurred about 10 min later. The rate of acetylation of liver nuclear proteins in 15 min incubation was significantly higher in "old ...
Liew, C C, Gornall, A G
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Posttranslational covalent modification of proteins.
Science (New York, N.Y.), 1978A search for derivatized amino acids in proteins has shown that the extent of posttranslational modification of proteins is quite substantial. While only 20 primary amino acids are specified in the genetic code and are involved as monomer building blocks in the assembly of the polypeptide chain, about 140 amino acids and amino acid derivatives have ...
R, Uy, F, Wold
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Amine‐Tagged Fragmented Ligand Installation for Covalent Modification of MOF‐74
Angewandte Chemie - International Edition, 2021Myoung Soo Lah, Min Kim, Jaewoong Lim
exaly