Results 161 to 170 of about 166,609 (297)

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. [PDF]

J Am Chem Soc, 2022
Zhang Z, Morstein J, Ecker AK, Guiley KZ, Shokat KM.   +4 more
europepmc   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

Covalent Modification by Click Mechanochemistry: Systematic Installation of Pendant OH Groups in a MOF for Rigidity Control and Luminescence-Based Water Detection. [PDF]

ACS Appl Mater Interfaces, 2023
Jędrzejowski D, Ryndak M, Zakrzewski JJ, Hodorowicz M, Chorazy S, Matoga D.   +5 more
europepmc   +1 more source

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source

Covalent Modification of Bromodomain Proteins by Peptides Containing a DNA Damage-Induced, Histone Post-Translational Modification. [PDF]

Chembiochem, 2022
Jacinto MP, Heidenreich D, Müller S, Greenberg MM.   +3 more
europepmc   +1 more source

Modification of proteins with covalent lipids

Progress in Lipid Research, 1988
openaire   +2 more sources

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Ultrasensitivity and bistability in covalent-modification cycles with positive autoregulation. [PDF]

Proc Math Phys Eng Sci, 2021
Jeynes-Smith C, Araujo RP.
europepmc   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. [PDF]

Angew Chem Int Ed Engl, 2021
Fan S, Yue L, Wan W, Zhang Y, Zhang B, Otomo C, Li Q, Lin T, Hu J, Xu P, Zhu M, Tao H, Chen Z, Li L, Ding H, Yao Z, Lu J, Wen Y, Zhang N, Tan M, Chen K, Xie Y, Otomo T, Zhou B, Jiang H, Dang Y, Luo C.   +26 more
europepmc   +1 more source