Results 91 to 100 of about 2,861,963 (268)
Iterative Selection of DNA Nanostructures for Cellular Uptake
Advanced Materials, EarlyView.DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar +4 more
wiley +1 more source
Covalently Linked DNA Nanotubes
, 2016 The present study introduces an approach to prepare covalently linked DNA nanotubes. A circular DNA that includes at its opposite poles thiol and amine functionalities acts as the building block for the construction of the DNA nanotubes. The circular DNA
Anja Henning (1993831) +3 more
core +2 more sources
HBV Life Cycle: Entry and Morphogenesis
Viruses, 2009 Hepatitis B virus (HBV) is a major cause of liver disease. HBV primarily infects hepatocytes by a still poorly understood mechanism. After an endocytotic process, the nucleocapsids are released into the cytoplasm and the relaxed circular rcDNA genome is ...
Stephanie Schädler, Eberhard Hildt
doaj +1 more source
A simple method for the preparation of covalently closed circular form of plasmid DNA
, 1988 peer reviewedWe describe a simple, rapid, inexpensive method for isolation of covalently closed circular plasmid DNA. The method involves the electrophoresis of crude DNA preparations in an agarose gel, electrotransfer onto a dialysis membrane and ...
Mercier, L. +2 more
core
, 2009 International audienceThe recently described hepatic cell line HepaRG is the sole hepatoma cell line susceptible to hepatitis B virus (HBV) infection. It provides a unique tool for investigating some unresolved issues of the virus' biology, particularly ...
Durantel, David +5 more
core +1 more source
Advanced Materials, EarlyView.Melt electrofibrillation (MEF) enables the fabrication of nanofibrillar PCL scaffolds with defined architectures that guide cellular alignment and retention during cartilage tissue engineering. Unlike conventional melt electrowriting, MEF consistently directs collagen type II‐rich extracellular matrix organization, providing a tunable platform to ...
Alba Pueyo Moliner +10 more
wiley +1 more source
Mechanisms of Hepatitis B Virus cccDNA and Minichromosome Formation and HBV Gene Transcription
VirusesHepatitis B virus (HBV) is the etiologic agent of chronic hepatitis B, which puts at least 300 million patients at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma.
Andoni Gómez-Moreno, Alexander Ploss
doaj +1 more source
Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.
PLoS ONE, 2019 Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and ...
Fumihiko Takeuchi +16 more
doaj +1 more source
Properties of Closed Circular DNA [PDF]
, 1971 A method for the measurement of the superhelix density, σ0, of a closed circular DNA from separation between fluorescent buoyant bands of nicked and closed circular forms in an ethidium bromide-CsCl equilibrium gradient is presented. Nicked and closed
Upholt, William Boyce
core +1 more source
Nature‐Derived Chitosan Biopolymer: A Promising Candidate for Sustainable Electronics
Advanced Materials Technologies, EarlyView.In the creation of environmentally friendly devices, nature‐derived chitosan biopolymer is a promising contender for sustainable electronic research. It can be utilized to create more ecologically friendly scalable gadgets and has a variety of uses in different active layers of electronics.
Joshua McDonald +3 more
wiley +1 more source