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Frontiers in Microbiology, 2022 Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Juan Chen, Ailong Huang
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Targeting HBV cccDNA Levels: Key to Achieving Complete Cure of Chronic Hepatitis B
PathogensChronic hepatitis B (CHB) caused by HBV infection has brought suffering to numerous people. Due to the stable existence of HBV cccDNA, the original template for HBV replication, chronic hepatitis B (CHB) is difficult to cure completely.
Renxia Zhang, Zhijin Zheng
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A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation—and Beyond?
Viruses, 2017 Chronic hepatitis B virus (HBV) infection puts more than 250 million people at a greatly increased risk to develop end-stage liver disease. Like all hepadnaviruses, HBV replicates via protein-primed reverse transcription of a pregenomic (pg) RNA ...
Sabrina Schreiner, Michael Nassal
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Research progress in hepatitis B virus covalently closed circular DNA
Cancer Biology & Medicine, 2022 Hepatitis B virus (HBV) infections are a global public health issue. HBV covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is a key factor in the HBV replication cycle.
Xiaodong Zhang, Yufei Wang, Guang Yang
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV), existing as a stable minichromosome in the hepatocyte, is responsible for persistent HBV infection.
Zhuanchang Wu +20 more
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Dynamics of Hepatitis B Virus Covalently Closed Circular DNA: A Mini-Review
Microorganisms, 2023 Eradication of cccDNA is an ideal goal of chronic hepatitis B (CHB) therapy. Understanding the changes in the cccDNA pool during therapy provides a basis for developing CHB treatment strategies.
Jie-Li Hu, Ai-Long Huang
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Scientific Reports, 2022 The persistence of covalently closed circular DNA (cccDNA) poses a major obstacle to curing chronic hepatitis B (CHB). Here, we used droplet digital PCR (ddPCR) for cccDNA quantitation.
Sanae Hayashi +11 more
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Transcription of hepatitis B virus covalently closed circular DNA is regulated by CpG methylation during chronic infection. [PDF]
PLoS ONE, 2014 The persistence of hepatitis B virus (HBV) infection is maintained by the nuclear viral covalently closed circular DNA (cccDNA), which serves as transcription template for viral mRNAs. Previous studies suggested that cccDNA contains methylation-prone CpG
Yongmei Zhang +12 more
doaj +1 more source
Annals of Hepatology, 2020 Introduction and objectives: HBV covalently closed circular (ccc) DNA is the key player in viral persistence and an important predictive biomarker for hepatitis relapse.
Ching-Yu Bao +5 more
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Frontiers in Microbiology, 2022 Hepatitis B virus (HBV) infection is still a serious public health problem worldwide. Antiviral therapies such as interferon and nucleos(t)ide analogs efficiently control HBV replication, but they cannot eradicate chronic hepatitis B (CHB) because of ...
Yuan Zhang +18 more
doaj +1 more source