Results 31 to 40 of about 6,841 (192)

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus. [PDF]

PLoS Pathogens, 2018
Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver diseases.
Kouichi Kitamura, Lusheng Que, Miyuki Shimadu, Miki Koura, Yuuki Ishihara, Kousho Wakae, Takashi Nakamura, Koichi Watashi, Takaji Wakita, Masamichi Muramatsu   +9 more
doaj   +3 more sources

Prediction of cccDNA dynamics in hepatitis B patients by a combination of serum surrogate markers. [PDF]

PLoS Computational Biology
Quantification of intrahepatic covalently closed circular DNA (cccDNA) is a key for evaluating an elimination of hepatitis B virus (HBV) in infected patients.
Kwang Su Kim, Masashi Iwamoto, Kosaku Kitagawa, Hyeongki Park, Sanae Hayashi, Senko Tsukuda, Takeshi Matsui, Masanori Atsukawa, Kentaro Matsuura, Natthaya Chuaypen, Pisit Tangkijvanich, Lena Allweiss, Takara Nishiyama, Naotoshi Nakamura, Yasuhisa Fujita, Eiryo Kawakami, Shinji Nakaoka, Masamichi Muramatsu, Kazuyuki Aihara, Takaji Wakita, Alan S Perelson, Maura Dandri, Koichi Watashi, Shingo Iwami, Yasuhito Tanaka   +24 more
doaj   +2 more sources

Tracking cccDNA in chronic HBV infection [PDF]

Hepatology, 2004
Hepatitis B virus (hepadnavirus) infections are maintained by the presence of a small and regulated number of episomal viral genomes [covalently closed circular DNA (cccDNA)] in the nuclei of infected cells. Although a number of studies have measured the mean copy number of cccDNA molecules in hepadnaviral-infected cells, the ...
Hans Christian Spangenberg, Robert Thimme, Hubert E. Blum, Hartmut Jaeschke, Kevin Mullen, Darius Moradpour   +5 more
openaire   +2 more sources

HBV cccDNA and Its Potential as a Therapeutic Target [PDF]

Journal of Clinical and Translational Hepatology, 2019
Chronic hepatitis B virus infection continues to be a major health burden worldwide. It can cause various degrees of liver damage and is strongly associated with the development of liver cirrhosis and hepatocellular carcinoma. Covalently closed circular DNA in the nucleus of infected cells cannot be disabled by present therapies which may lead to HBV ...
Zhu, Anjing, Liao, Xinzhong, Li, Shuang, Zhao, Hang, Chen, Limin, Xu, Min, Duan, Xiaoqiong   +6 more
openaire   +2 more sources

cccDNA-Targeted Drug Screen Reveals a Class of Antihistamines as Suppressors of HBV Genome Levels

Biomolecules, 2023
Chronic infection with hepatitis B virus (HBV) is incurable, as the current therapeutics cannot eliminate its persistent genomic material, cccDNA. Screening systems for cccDNA-targeting therapeutics are unavailable, as low copies of cccDNA in vitro ...
Ee Chee Ren, Nicole Ziyi Zhuo, Zhi Yi Goh, Isabelle Bonne, Benoît Malleret, Hui Ling Ko   +5 more
doaj   +1 more source

Hepatitis B virus cccDNA clearance [PDF]

Hepatology, 2005
Chronic hepadnavirus infections cause liver damage with ongoing death and regeneration of hepatocytes. In the present study, we set out to quantify the extent of liver turnover by measuring the clonal proliferation of hepatocytes by using integrated viral DNA as a genetic marker for individual hepatocyte lineages.
Maura Dandri, Jorg Petersen, Hartmut Jaeschke, Kevin Mullen, Darius Moradpour   +4 more
openaire   +2 more sources

Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.: cccDNA levels in chronic hepatitis B patients [PDF]

, 2004
BACKGROUND & AIMS: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate responsible for persistent infection of hepatocytes.
Zoulim, Fabien, Goodman, Zachary, Delaney, William, E., Brosgart, Carol, L., Chen, Shan-Shan, Marcellin, Patrick, Bowden, Scott, Petersen, Jorg, Lau, George, Trepo, Christian, Werle-Lapostolle, Bettina, Xiong, Shelly, Wursthorn, Karsten, Locarnini, Stephen, Gibbs, Craig, S.   +14 more
core   +3 more sources

Epigenetic modification and regulation of HBV cccDNA [PDF]

Chinese Science Bulletin, 2019
Hepatitis B virus (HBV) infection, which can cause acute or chronic viral hepatitis, hepatic fibrosis, cirrhosis, and carcinoma (HCC), is a major global health problem. After the virus enters a hepatocyte, its genome translocates into the cell nucleus and forms covalently closed circular DNA (cccDNA).
Yifei Yuan, Xinwen Chen, Chunchen Wu
openaire   +1 more source

PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA

Cell Death and Disease, 2022
Hepatitis B virus infection remains a major health problem worldwide due to its high risk of liver failure and hepatocellular carcinoma. Covalently closed circular DNA (cccDNA), which is present as an individual minichromosome, serves as the template for
Yao Fan, Yi Liang, Yu Liu, Hui Fan
doaj   +1 more source

Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: molecular mechanisms and clinical significance

Emerging Microbes and Infections, 2014
Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV). Extensive research over the past decades has unveiled the important role of cccDNA in the natural history and antiviral treatment of chronic HBV infection.
Hung-Chih Yang, Jia-Horng Kao
doaj   +1 more source