Results 51 to 60 of about 6,841 (192)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Current Status and Challenges in Anti-Hepatitis B Virus Agents Based on Inactivation/Inhibition or Elimination of Hepatitis B Virus Covalently Closed Circular DNA

Viruses, 2023
There has been over half a century since the discovery of hepatitis B virus (HBV) to now, but approximately 300 million patients with chronic hepatitis B (CHB) still live in the world, resulting in about one million deaths every year.
An-Qi Zhuang, Yan Chen, Shan-Mei Chen, Wen-Cheng Liu, Yao Li, Wen-Jie Zhang, Yi-Hang Wu   +6 more
doaj   +1 more source

Advances in Viral Markers for Predicting Functional Cure of Chronic Hepatitis B

Portal Hypertension &Cirrhosis, EarlyView.
Functional cure, defined as sustained hepatitis B surface antigen (HBsAg) loss, is achieved by only a minority of patients with chronic hepatitis B (CHB); early identification of likely responders may improve cure rates and reduce costs. However, responses to antiviral therapy vary considerably, necessitating reliable hepatitis B virus (HBV) viral ...
Xinrong Lu, Xin Yang, Qishui Ou, Zhen Xun   +3 more
wiley   +1 more source

An Immortalized Hepatocyte-Like Cell Line (imHC) Accommodated Complete Viral Lifecycle, Viral Persistence Form, cccDNA and Eventual Spreading of a Clinically-Isolated HBV

Viruses, 2019
More than 350 million people worldwide have been persistently infected with the hepatitis B virus (HBV). Chronic HBV infection could advance toward liver cirrhosis and hepatocellular carcinoma.
Khanit Sa-ngiamsuntorn, Piyanoot Thongsri, Yongyut Pewkliang, Adisak Wongkajornsilp, Pattida Kongsomboonchoke, Phichaya Suthivanich, Suparerk Borwornpinyo, Suradej Hongeng   +7 more
doaj   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

CTCF regulates hepatitis B virus cccDNA chromatin topology

Journal of General Virology, 2023
Hepatitis B Virus (HBV) is a small DNA virus that replicates via an episomal covalently closed circular DNA (cccDNA) that serves as the transcriptional template for viral mRNAs. The host protein, CCCTC-binding factor (CTCF), is a key regulator of cellular transcription by maintaining epigenetic boundaries, nucleosome phasing ...
Mihaela Olivia Dobrica, Christy Susan Varghese, James M Harris, Jack Ferguson, Andrea Magri, Roland Arnold, Csilla Várnai, Joanna L Parish, Jane A McKeating   +8 more
openaire   +2 more sources

Hepatitis B in Organ Transplantation—Current Evidence and Clinical Gaps

Transplant Infectious Disease, EarlyView.
ABSTRACT Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through immunization. Despite this, HBV remains a leading cause of chronic liver disease globally, affecting over 250 million people.
Oscar A. Fernandez‐Garcia, Britta L. Hirsch, Irene A. Abela, Karen E. Doucette   +3 more
wiley   +1 more source

Hepatitis B Pre-genomic RNA as Biomarkers for the Evaluation of Liver Fibrosis and Severity of the Disease in Patients with Chronic Hepatitis B Infection

Medical Journal of Babylon
Background: The key reason for the persistence of the hepatitis B virus (HBV) is intrahepatic covalently closed circular DNA (cccDNA). Therefore, a noninvasive serum biomarker that can indicate intrahepatic cccDNA is necessary for assessing the ...
Estabrak Ali Toama Al-Hmadani, Ahmed Sahib Abdulamir   +1 more
doaj   +1 more source

Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro

Microorganisms, 2019
Background: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is the major cause of viral persistence in patients with chronic HBV infection.
Sergey Brezgin, Anastasiia Kostyusheva, Ekaterina Bayurova, Ilya Gordeychuk, Maria Isaguliants, Irina Goptar, Anastasiia Nikiforova, Valery Smirnov, Elena Volchkova, Dieter Glebe, Dmitry Kostyushev, Vladimir Chulanov   +11 more
doaj   +1 more source

New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation

Cells, 2020
The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease ...
Alexander L. Marchetti, Haitao Guo
doaj   +1 more source