Results 61 to 70 of about 6,841 (192)
Transfusion, EarlyView.Abstract Background Blood donor screening occasionally identifies individuals with high HBV surface antigen (HBsAg) levels despite undetectable or extremely low HBV DNA. Molecular basis and transfusion risk of this discordant profile remain unclear. Study Design and Methods Seventy‐five blood donors with HBsAg >100 IU/mL and undetectable or very low ...
Maelenn Païline Delcourt +8 more
wiley +1 more source
mBioThe persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key obstacle for HBV cure. This study aims to comprehensively assess the effect of interferon (IFN) and small-interfering RNA (siRNA) combination on the cccDNA ...
Kongying Hu +10 more
doaj +1 more source
Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome [PDF]
Clinical and Molecular HepatologyBackground/Aims Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interact with histone ...
Sheng-Tao Cheng +12 more
doaj +1 more source
Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation
Advanced Science, Volume 13, Issue 53, 24 September 2026.Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan +11 more
wiley +1 more source
, 2022 Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890) +24 more
core +1 more source
The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo +4 more
wiley +1 more source
Replication-driven HBV cccDNA loss in chimeric mice with humanized livers
Journal of VirologyHepatitis B virus (HBV) infection depends on the establishment of covalently closed circular DNA (cccDNA) and can be either transient or persistent. Persistent infection requires a noncytopathic viral phenotype, primarily achieved by limiting replication
Bai-Hua Zhang +5 more
doaj +1 more source
Detection of HBV Covalently Closed Circular DNA
Viruses, 2017 Chronic hepatitis B virus (HBV) infection affects approximately 240 million people worldwide and remains a serious public health concern because its complete cure is impossible with current treatments.
Xiaoling Li +3 more
doaj +1 more source
Emerging Microbes and Infections, 2020 HBV cccDNA stably exists in the nuclei of infected cells as an episomal munichromosome which is responsible for viral persistence and failure of current antiviral treatments.
Congle Shen +8 more
doaj +1 more source
Next‐Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study
Journal of Medical Virology, Volume 98, Issue 9, September 2026.ABSTRACT This multicentre study investigated the utility of next‐generation sequencing (NGS) to detect and generate hepatitis B virus (HBV) genomes in samples of low viral load (from 0.2 to 6207 IU/mL). 23 HBV DNA‐positive plasma samples of genotypes A‐E and one HBV‐negative control sample were assayed blindly via 9 established NGS methods from 6 ...
Michael X. Fu +28 more
wiley +1 more source