Results 71 to 80 of about 6,841 (192)
Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA [PDF]
Molecular Therapy, 2016 Hepatitis B virus (HBV) causes chronic infections that cannot yet be cured. The virus persists in infected hepatocytes, because covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is stable in nondividing cells. Antiviral therapies with nucleoside analogues inhibit HBV DNA synthesis in capsids in the cytoplasm of ...
Seeger, Christoph, Sohn, Ji A
openaire +2 more sources
DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy
MedComm, Volume 7, Issue 9, September 2026.This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu +6 more
wiley +1 more source
, 2022 Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890) +24 more
core +1 more source
Gene Therapy for Chronic HBV—Can We Eliminate cccDNA? [PDF]
Genes, 2018 Chronic infection with the hepatitis B virus (HBV) is a global health concern and accounts for approximately 1 million deaths annually. Amongst other limitations of current anti-HBV treatment, failure to eliminate the viral covalently closed circular DNA (cccDNA) and emergence of resistance remain the most worrisome.
Kristie Bloom +3 more
openaire +2 more sources
Alimentary Pharmacology &Therapeutics, Volume 64, Issue 5, Page 625-634, September 2026.HBV reactivation incidence varied across immunosuppressive and chemotherapeutic agents. Clinically meaningful HBV reactivation was also observed in patients receiving corticosteroids and conventional immunosuppressive therapies. ABSTRACT Background Data on the incidence of hepatitis B virus reactivation (HBVr) remain limited. In Japan, patients who are
Kazuhiko Ikeuchi +8 more
wiley +1 more source
G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation
Advanced Science, Volume 13, Issue 45, 13 August 2026.G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang +5 more
wiley +1 more source
Possible dynamics of HBV cccDNA between vector delivery doses.
, 2013 (a) Cell death inducing decay of incorporated episome. (b) Episomal degradation. (c) cccDNA expansion despite suppressive antiviral therapy. (d) Hepatocyte replication with equal dispersion of cccDNA molecules between cells.
Keith R. Jerome (356247) +3 more
core +1 more source
, 2022 Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890) +24 more
core +1 more source
, 2023 International audienceObjectives A major goal of curative hepatitis B virus (HBV) treatments is the reduction or inactivation of intrahepatic viral covalently closed circular DNA (cccDNA).
Haitao Guo +28 more
core +1 more source
Attacking hepatitis B virus cccDNA - The holy grail to hepatitis B cure.
, 2016 HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle.
Lucifora, Julie;Protzer, Ulrike
core +2 more sources