New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation [PDF]
Cells, 2020 The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease ...
Alexander L. Marchetti, Haitao Guo
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Conversion of hepatitis B virus relaxed circular to covalently closed circular DNA is supported in murine cells [PDF]
JHEP Reports, 2022 Background & Aims: HBV has a narrow host restriction, with humans and chimpanzees representing the only known natural hosts. The molecular correlates of resistance in species that are commonly used in biomedical research, such as mice, are currently ...
Lei Wei +6 more
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Detection of HBV Covalently Closed Circular DNA [PDF]
Viruses, 2017 Chronic hepatitis B virus (HBV) infection affects approximately 240 million people worldwide and remains a serious public health concern because its complete cure is impossible with current treatments.
Xiaoling Li +3 more
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Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA [PDF]
Emerging Microbes and Infections, 2017 The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue.
Magda Rybicka +5 more
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Approaches to quantifying hepatitis B virus covalently closed circular DNA [PDF]
Clinical and Molecular Hepatology, 2022 Chronic hepatitis B is a major cause of liver disease worldwide and is currently incurable. Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is a key form of the virus responsible for its persistence and is the transcriptional template for ...
Henrik Zhang, Thomas Tu
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Research progress in hepatitis B virus covalently closed circular DNA [PDF]
Cancer Biology & Medicine, 2022 Hepatitis B virus (HBV) infections are a global public health issue. HBV covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is a key factor in the HBV replication cycle.
Xiaodong Zhang, Yufei Wang, Guang Yang
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Dynamics of Hepatitis B Virus Covalently Closed Circular DNA: A Mini-Review [PDF]
Microorganisms, 2023 Eradication of cccDNA is an ideal goal of chronic hepatitis B (CHB) therapy. Understanding the changes in the cccDNA pool during therapy provides a basis for developing CHB treatment strategies.
Jie-Li Hu, Ai-Long Huang
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The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. [PDF]
PLoS Pathogens, 2017 Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence.
Quanxin Long +11 more
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CRISPR-Cas9 Targeting of Hepatitis B Virus Covalently Closed Circular DNA Generates Transcriptionally Active Episomal Variants [PDF]
mBio, 2022 Chronic hepatitis B virus (HBV) infection persists due to the lack of therapies that effectively target the HBV covalently closed circular DNA (cccDNA). We used HBV-specific guide RNAs (gRNAs) and CRISPR-Cas9 and determined the fate of cccDNA after gene ...
Maria Guadalupe Martinez +10 more
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Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx [PDF]
Frontiers in Microbiology, 2022 Hepatitis B virus (HBV) infection is still a serious public health problem worldwide. Antiviral therapies such as interferon and nucleos(t)ide analogs efficiently control HBV replication, but they cannot eradicate chronic hepatitis B (CHB) because of ...
Yuan Zhang +18 more
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