Results 21 to 30 of about 2,861,963 (268)
PLoS Pathogens, 2020 Hepatitis B virus (HBV) delivers a partially double-stranded, relaxed circular (RC) DNA genome in complete virions to the host cell nucleus for conversion to the covalently closed circular (CCC) DNA, which establishes and sustains viral infection.
Jun Luo, Ji Xi, Lu Gao, Jianming Hu
doaj +2 more sources
Emerging Microbes and Infections, 2014 Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV). Extensive research over the past decades has unveiled the important role of cccDNA in the natural history and antiviral treatment of chronic HBV infection.
Hung-Chih Yang, Jia-Horng Kao
doaj +3 more sources
A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2022 Yuchen Xia, Kaitao Zhao, Chengliang Zhu
exaly +2 more sources
Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma [PDF]
International Journal of Hepatology, 2013 Pregenomic RNA (pgRNA) is generated from covalently closed circular DNA (cccDNA) and plays important roles in viral genome amplification and replication. Hepatic pgRNA and cccDNA expression levels indicate viral persistence and replication activity. This
Fugui Bai +15 more
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Cyclocytidine hydrochloride inhibits the synthesis of relaxed circular DNA of hepatitis B virus [PDF]
PeerJ, 2022 Background Cyclocytidine hydrochloride (HCl) has been reported to inhibit DNA synthesis by affecting DNA polymerase. Here, we tested the antiviral effect of cyclocytidine on hepatitis B virus (HBV) DNA synthesis, which is reliant on DNA polymerase ...
Xue Wang +7 more
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Covalently closed circular DNAs in closely related unicellular cyanobacteria [PDF]
Journal of Bacteriology, 1979 Plasmids of Synechococcus cedrorum and two Anacytsis nidulans strains were characterized physically, and a probable instance of spontaneous "curing" is described.
R H, Lau, W F, Doolittle
openaire +2 more sources
Hepatitis B virus cccDNA is formed through distinct repair processes of each strand
Nature Communications, 2021 HBV covalently closed circular DNA (cccDNA) enables and persists in chronic infection, but the molecular mechanism of its formation is unclear. Here, Wei and Ploss elucidate the detailed kinetics and biochemical steps by which the relaxed circular DNA is
Lei Wei, Alexander Ploss
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Frontiers in Cellular and Infection Microbiology, 2023 Occult hepatitis B virus (HBV) infection (OBI) is a condition in which replication-competent viral DNA is detected in the liver (with detectable or undetectable HBV DNA in serum) of individual testing negative for HBV surface antigen (HBsAg).
Chengwei Wang +4 more
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Circular DNA's from HeLa cell nuclei and mitochondria [PDF]
, 1970 An electron microscopic observation was made on the DNA's extracted from purified HeLa cell nuclei, mitochondria, and the whole cell, and fractionated by ethidium bromide-cesium chloride density gradient method or sucrose density gradient method. Nuclear
Oda, Takuzo +4 more
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Журнал микробиологии, эпидемиологии и иммунобиологии, 2016 Aim. Evaluate significance of covalently closed circular DNA of hepatitis В virus as a marker for detection of occult viral hepatitis В in Uzbekistan population with hepatitis of various genesis. Materials and methods.
A. V. Semenov +6 more
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