Mitochondrial DNA from hamster tumors induced by adenovirus type 12 [PDF]
, 1970 1. Mitochondria isolated from hamster tumors induced by adenovirus type 12 possessed circular DNA fibers. 2. The mean value of the length of the highest frequency group of the circular DNA molecules was 4.92 ±0.38 μ. 3. Catenated dimer DNA molecules
Oda, Takuzo, Nishida, Shigeru
core +1 more source
Журнал инфектологии, 2016 Objective: To evaluate relationships between virological and morphological data in patients with chronic hepatitis B in phase immune control and reactivation.Materials and methods: The study involved 46 patients with chronic hepatitis B, indicators ...
I. A. Gabdrakhmanov +12 more
doaj +1 more source
Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification [PDF]
Journal of Virology, 1990 Primary duck hepatocytes were infected with a mutant duck hepatitis B virus defective in envelope protein but competent for viral DNA synthesis. Cells infected by this mutant accumulated higher levels of viral covalently closed, circular DNA (cccDNA) than those infected by wild-type virus.
J, Summers, P M, Smith, A L, Horwich
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Physical Characterization of Gemini Surfactant-Based Synthetic Vectors for the Delivery of Linear Covalently Closed (LCC) DNA Ministrings. [PDF]
PLoS ONE, 2015 In combination with novel linear covalently closed (LCC) DNA minivectors, referred to as DNA ministrings, a gemini surfactant-based synthetic vector for gene delivery has been shown to exhibit enhanced delivery and bioavailability while offering a ...
Chi Hong Sum +3 more
doaj +1 more source
Renaturation of denatured, covalently closed circular DNA.
Journal of Biological Chemistry, 1981 The rate of renaturation of denatured, covalently closed, circular DNA (form Id DNA) of the phi X174 replicative form has been investigated as a function of pH, temperature, and ionic strength. The rate at a constant temperature is a sharply peaked function of pH in the range of pH 9 to 12.
W, Strider, M N, Camien, R C, Warner
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DNA Ministrings: Highly Safe and Effective Gene Delivery Vectors
Molecular Therapy: Nucleic Acids, 2014 Conventional plasmid DNA vectors play a significant role in gene therapy, but they also have considerable limitations: they can elicit adverse immune responses because of bacterial sequences they contain for maintenance and amplification in prokaryotes ...
Nafiseh Nafissi +5 more
doaj +1 more source
Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells
JHEP Reports, 2022 Background & Aims: The chronicity of HBV (and resultant liver disease) is determined by intrahepatic persistence of the HBV covalently closed circular DNA (cccDNA), an episomal form that encodes all viral transcripts.
Thomas Tu +9 more
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Effect of nucleos(t)ide analogues therapy on HBsAg, intrahepatic HBV DNA and covalently closed circular DNA levels [PDF]
, 2012 BACKGROUND: We aimed to study 1) the effects of 1-year nucleos(t)ide analogue (NA) therapy on HBsAg and covalently closed circular DNA (cccDNA) levels; and 2) the possible use of HBsAg reduction as a marker for cccDNA reduction. METHODS: We recruited 124
Fung, J +5 more
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Hepatitis B Virus Covalently Closed Circular DNA Predicts Postoperative Liver Cancer Metastasis Independent of Virological Suppression. [PDF]
Cancers (Basel), 2021 New antiviral therapies against hepatitis B virus (HBV) focus on the elimination of covalently closed circular DNA (cccDNA). However, traditional cccDNA-specific quantitative PCR (qPCR) has a narrow effective range, hindering a reliable comparison ...
Hsu CW +6 more
europepmc +2 more sources
Characterization of Nucleosome Positioning in Hepadnaviral Covalently Closed Circular DNA Minichromosomes [PDF]
Journal of Virology, 2012 ABSTRACTHepadnaviral covalently closed circular DNA (cccDNA) exists as an episomal minichromosome in the nucleus of virus-infected hepatocytes, and serves as the transcriptional template for the synthesis of viral mRNAs. To obtain insight on the structure of hepadnaviral cccDNA minichromosomes, we utilized ducks infected with the duck hepatitis B virus
Liping, Shi +7 more
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