Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus Covalently Closed Circular DNA Formation
mBio, 2020 The covalently closed circular (CCC) DNA of hepatitis B virus (HBV) functions as the only viral transcriptional template capable of producing all viral RNA species and is essential to initiate and sustain viral replication.
Jun Luo +5 more
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Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA [PDF]
Genes and DiseasesHuman hepatitis B virus (HBV) infection is the major cause of acute and chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma. Although the application of prophylactic vaccination programs has successfully prevented the trend of increasing ...
Jihua Ren +8 more
doaj +3 more sources
Covalently closed circular DNA [PDF]
Journal of hepatology, 2021 Current antiviral therapies, such as pegylated interferon-α and nucleos(t)ide analogues, effectively improve the quality of life of patients with chronic hepatitis B. However, they can only control the infection rather than curing infected hepatocytes.
Martinez, Maria Guadalupe +4 more
core +4 more sources
Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation [PDF]
Viruses, 2023 Hepatitis B virus (HBV) relies on the core protein (HBc) to establish productive infection, as defined by the formation of the covalently closed circularized DNA (cccDNA), as well as to carry out almost every step of the lifecycle following cccDNA ...
Megan A. Mendenhall +2 more
doaj +2 more sources
Chronic Hepatitis B Genotype C Mouse Model with Persistent Covalently Closed Circular DNA [PDF]
VirusesHepatitis B virus (HBV) can cause chronic infections, significantly increasing the risk of death from cirrhosis and hepatocellular carcinoma (HCC). A key player in chronic HBV infection is covalently closed circular DNA (cccDNA), a stable episomal form ...
Deok-Hwa Seo +7 more
doaj +2 more sources
PLoS Pathogens, 2019 Persistent hepatitis B virus (HBV) infection relies on the establishment and maintenance of covalently closed circular (ccc) DNA, a 3.2 kb episome that serves as a viral transcription template, in the nucleus of an infected hepatocyte.
Liudi Tang +4 more
doaj +2 more sources
Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation. [PDF]
PLoS ONE, 2012 Synthesis of the covalently closed circular (ccc) DNA is a critical, but not well-understood step in the life cycle of hepadnaviruses. Our previous studies favor a model that removal of genome-linked viral DNA polymerase occurs in the cytoplasm and the ...
Haitao Guo +4 more
doaj +2 more sources
Hepatitis B Virus Covalently Closed Circular DNA Chromatin Immunoprecipitation Assay. [PDF]
Methods Mol BiolHepatitis B virus (HBV) is an obligate human hepatotropic DNA virus causing both transient and chronic infection. The livers of chronic hepatitis B patients have a high risk of developing liver fibrosis, cirrhosis, and hepatocellular carcinoma. The nuclear episomal viral DNA intermediate, covalently closed circular DNA (cccDNA), forms a highly stable ...
Kim ES, Guo H.
europepmc +3 more sources
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1 [PDF]
Advanced Science, 2022 Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form minichromosome in the nucleus and is resistant to antiviral agents.
Yang Sun +15 more
doaj +2 more sources
Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner. [PDF]
PLoS Pathogens, 2010 Persistence of hepatitis B virus (HBV) infection requires covalently closed circular (ccc)DNA formation and amplification, which can occur via intracellular recycling of the viral polymerase-linked relaxed circular (rc) DNA genomes present in virions ...
Josef Köck +5 more
doaj +2 more sources