Results 91 to 100 of about 6,841 (192)

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

, 2009
HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and cellular proteins.
BELLONI, Laura, T. Pollicino, F. De Nicola, GUERRIERI, Francesca, G. Raffa, M. Fanciulli, LEVRERO, Massimo, G. Raimondo   +7 more
core   +1 more source

Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status [PDF]

, 2016
In chronic hepatitis B virus (HBV) infection, variants with mutations in the basal core promoter (BCP) and precore region predominate and associate with more severe disease forms.
Raimando, Giovanni, Khakoo, S, Pollicino, Teresa, Stampoulis, Dimitrios, Khakoo, Salim, Pollicino, T, Raimondo, G, Karayiannis, Peter, Koumbi, L, Stampoulis, D, Karayiannis, P, Koumbi, Lemonica   +11 more
core   +1 more source

Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome.

PLoS Pathogens
Chronic hepatitis B virus (HBV) infection can significantly increase the incidence of cirrhosis and liver cancer, and there is no curative treatment.
Kaitao Zhao, Jingjing Wang, Zichen Wang, Mengfei Wang, Chen Li, Zaichao Xu, Qiong Zhan, Fangteng Guo, Xiaoming Cheng, Yuchen Xia   +9 more
doaj   +1 more source

Scavenger Receptor Class F Member 2: An Intracellular Receptor Escorting Hepatitis B Virus From Endosome to Nuclear Pore

MedComm – Future Medicine, Volume 5, Issue 3, September 2026.
Yujing Ng, Lin Du, Huahao Fan
wiley   +1 more source

Image_1_KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome.TIF

, 2022
Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890), Fan Li (49953), Si-Yu Yuan (11991191), Xu Wen (2708356), Mei-Ling Dong (11991200), Jing Liu (38537), Yuan Zhang (41832), Min-Li Yang (11991197), Hai-Bo Yu (2406934), Yu-Jiao Zhou (11991194), Da-Peng Zhang (802906), Fang Ren (819350), Juan Chen (61123), Hui Zhang (7197), Ai-Long Huang (3181887), Qing Wang (27728), Yi-Ping Qin (8132244), Zhen Yang (107412), Yao Chen (149006), Sheng-Tao Cheng (4110184), Hong-Zhong Zhou (3181878), Ming Tan (34506), Wei-Xian Chen (540311), Xin He (48101), Zhi-Hong Li (1523968)   +24 more
core   +1 more source

Mutational analysis of HBV cccDNA in HCC patients.

, 2016
A. Agarose gel analysis of 3D-PCR of cccDNA from CT and CNCT of samples from patients #110, #178, #161and #155. cccDNA was specifically amplified by RCA, then the concatemerized product was analysis by 3D-PCR using a denaturation temperature gradient of ...
Yanmeng Chen (2839214), John E. Tavis (46579), Ailong Huang (196688), Yao Huang (216100), Xuan Luo (270185), Zeng Tu (2839211), Yuan Hu (275971), Jieli Hu (2839217)   +7 more
core   +1 more source

Image_9_KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome.TIF

, 2022
Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890), Fan Li (49953), Si-Yu Yuan (11991191), Xu Wen (2708356), Mei-Ling Dong (11991200), Jing Liu (38537), Yuan Zhang (41832), Min-Li Yang (11991197), Hai-Bo Yu (2406934), Yu-Jiao Zhou (11991194), Da-Peng Zhang (802906), Fang Ren (819350), Juan Chen (61123), Hui Zhang (7197), Ai-Long Huang (3181887), Qing Wang (27728), Yi-Ping Qin (8132244), Zhen Yang (107412), Yao Chen (149006), Sheng-Tao Cheng (4110184), Hong-Zhong Zhou (3181878), Ming Tan (34506), Wei-Xian Chen (540311), Xin He (48101), Zhi-Hong Li (1523968)   +24 more
core   +1 more source

Research progress in occult hepatitis B virus infection and its transmission via blood transfusion

Zhongguo shuxue zazhi
In recent years, the development of nucleic acid testing (NAT) have significantly reduced the risk of hepatitis B virus (HBV) transmission through blood transfusion. However, a residual risk persists.
WANG Rui, WANG Bo, YU Yang
doaj   +1 more source

Image_11_KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome.TIF

, 2022
Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890), Fan Li (49953), Si-Yu Yuan (11991191), Xu Wen (2708356), Mei-Ling Dong (11991200), Jing Liu (38537), Yuan Zhang (41832), Min-Li Yang (11991197), Hai-Bo Yu (2406934), Yu-Jiao Zhou (11991194), Da-Peng Zhang (802906), Fang Ren (819350), Juan Chen (61123), Hui Zhang (7197), Ai-Long Huang (3181887), Qing Wang (27728), Yi-Ping Qin (8132244), Zhen Yang (107412), Yao Chen (149006), Sheng-Tao Cheng (4110184), Hong-Zhong Zhou (3181878), Ming Tan (34506), Wei-Xian Chen (540311), Xin He (48101), Zhi-Hong Li (1523968)   +24 more
core   +1 more source

Levels of cccDNA and HBV RNA in vivo and in vitro.

, 2013
The cccDNA levels (A) and pgRNA per cccDNA (B), as well as pgRNA/cccDNA ratios (C) were higher in liver tissue from HBeAg-positive as compared with HBeAg-negative patients.
Charles Hannoun (315101), Magnus Lindh (315102), Sebastian Malmström (315099), Simon B. Larsson (315100)   +3 more
core   +1 more source