Results 101 to 110 of about 6,841 (192)
Bio-Protocol, 2019 Persistence of the human hepatitis B virus (HBV) requires the maintenance of covalently closed circular (ccc)DNA, the episomal genome reservoir in nuclei of infected hepatocytes.
Bingqian Qu, Stephan Urban
doaj +1 more source
, 2022 Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890) +24 more
core +1 more source
, 2022 Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890) +24 more
core +1 more source
Effect of APE1 treatment on detection of cccDNA levels in 35 paired CT and CNCT samples.
, 2016 The 35 paired HCC samples with detectable cccDNA values (left column, N = 35) were divided into two group according to ratio of cccDNA in the paired CT and CNCT samples (CT/CNCT) 1 (right column, N = 10).
Yanmeng Chen (2839214) +7 more
core +1 more source
BiomoleculesHepatitis B virus (HBV) is a major global health issue, with an estimated 254 million people living with chronic HBV infection worldwide as of 2022. Chronic HBV infection is the leading cause of cirrhosis and liver cancer. Current treatment with nucleos(t)ide analogs is effective in the suppression of viral activity but generally requires lifelong ...
André Boonstra, Gulce Sari
openaire +3 more sources
CEP290 is Associated With Chromatin Accessibility of Hepatitis B virus cccDNA
Journal of Molecular BiologyHepatitis B virus (HBV) covalently closed circular DNA (cccDNA) serves as a stable nuclear template for viral transcription, yet the mechanisms controlling its chromatin accessibility remain poorly understood. Here, we performed single-cell assay for transposase-accessible chromatin sequencing (ATAC-seq) in HBV-infected human hepatocytes to profile ...
Sadahiro Iwabuchi +7 more
openaire +2 more sources
Chronic Hepatitis B Genotype C Mouse Model with Persistent Covalently Closed Circular DNA
VirusesHepatitis B virus (HBV) can cause chronic infections, significantly increasing the risk of death from cirrhosis and hepatocellular carcinoma (HCC). A key player in chronic HBV infection is covalently closed circular DNA (cccDNA), a stable episomal form ...
Deok-Hwa Seo +7 more
doaj +1 more source
The Journal of Clinical InvestigationThe cornerstone of functional cure for chronic hepatitis B (CHB) is hepatitis B surface antigen (HBsAg) loss from blood. HBsAg is encoded by covalently closed circular DNA (cccDNA) and HBV DNA integrated into the host genome (iDNA). Nucleos(t)ide analogs
Maraake Taddese +15 more
doaj +1 more source
DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication
Advanced ScienceHepatitis B virus (HBV) covalently closed circular DNA (cccDNA) contributes to viral persistence and recurrence, however, how the host innate immune system responds to cccDNA is still less known.
Caiyue Ren +15 more
doaj +1 more source
Molecular Therapy: Methods & Clinical DevelopmentThe hepatitis B virus (HBV) infects many people worldwide. As HBV infection frequently leads to liver fibrosis and carcinogenesis, developing anti-HBV therapeutic drugs is urgent.
Hikari Okada +11 more
doaj +1 more source