Results 1 to 10 of about 7,865 (134)

Natural products targeting hepatitis B virus X protein and HBx-associated pathways in HBV-related hepatocellular carcinoma: mechanisms and therapeutic potential [PDF]

Pharmaceutical Biology
Context Hepatocellular carcinoma (HCC), largely driven by chronic hepatitis B virus (HBV) infection, remains a major global health challenge with limited curative options in advanced stages.
Thu Ngoc Anh Nguyen, Piyanoot Thongsri, Yongyut Pewkliang, Mullika Traidej Chomnawang, Krit Thirapanmethee, Khanit Sa-ngiamsuntorn   +5 more
doaj   +2 more sources

HBx Induces the Production of N-GPC3 in Hepatoma Cells to Promote the Evasion of Macrophage Phagocytosis Through Activating Furin. [PDF]

J Cell Mol Med
ABSTRACT The hepatitis B virus X protein (HBx) is a central oncogenic driver in hepatocellular carcinoma (HCC). Although glypican‐3 (GPC3) is a phosphatidylinositol proteoglycan‐specific biomarker for HCC. However, the combined role of HBx and GPC3 in mediating HCC cell evasion from macrophage phagocytosis remains unclear. Here, we demonstrate that HBx
Wu J, Yu H, Zhou Y, Lin Y, Zhang K, Li W, Liu Z, Li M, Gao L.   +8 more
europepmc   +2 more sources

HBx Downregulates TFEB via the CUL4A/CUL4B–DDB1 Axis to Disrupt Lysosomal Function in Hepatocellular Carcinoma Cells [PDF]

Cells
Hepatitis B virus (HBV) infection remains a major global health burden, with chronic infection leading to severe liver diseases including cirrhosis and hepatocellular carcinoma (HCC). HBV-encoded X protein (HBx) plays a critical role in viral replication
Chunyan Zhang, Yuanping Han, Huan Yang
doaj   +2 more sources

HBx-mediated GPT2 suppression promotes liver cancer development by downregulating ADH1A [PDF]

Cancer Biology & Medicine
Objective: Hepatitis B virus (HBV) is the primary driver of liver cancer (LC), a malignancy characterized by extensive metabolic reprogramming.
Hongjuan You, Xing Wang, Ruyu Liu, Yuxin Wang, Huanyang Zhang, Lihong Ma, Ensi Bao, Yujie Zhong, Xiangye Liu, Delong Kong, Xiucheng Pan, Xiaocui Li, Suping Qin, Kuiyang Zheng, Chen Li, Renxian Tang, Fanyun Kong   +16 more
doaj   +2 more sources

The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma

Frontiers in Oncology, 2022
We aimed to elucidate the mechanism by which hepatitis B virus X (HBx) mutations increase the occurrence of hepatocellular carcinoma (HCC) and identify novel putative therapeutic targets. Wild-type HBx (WT-HBx) and four HBx mutants (M1, A1762T/G1764A; M2,
Rui Pu, Wenbin Liu, Xinyu Zhou, Xi Chen, Xiaomei Hou, Shiliang Cai, Liping Chen, Jianfeng Wu, Fan Yang, Xiaojie Tan, Jianhua Yin, Xin Wang, Guangwen Cao   +12 more
doaj   +1 more source

CUL4B facilitates HBV replication by promoting HBx stabilization

Cancer Biology & Medicine, 2022
Objective: Hepatitis B virus (HBV) infection is a major public health problem worldwide. However, the regulatory mechanisms underlying HBV replication remain unclear.
Haixia Shan, Bo Wang, Xiaodong Zhang, Hui Song, Xi Li, Yongxin Zou, Baichun Jiang, Huili Hu, Hao Dou, Changshun Shao, Lifen Gao, Chunhong Ma, Xiaoyun Yang, Xiaohong Liang, Yaoqin Gong   +14 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

HBx promotes liver tumor in mice by inhibiting microRNA-145a-5p

Di-san junyi daxue xuebao, 2021
Objective To investigate the changes of miRNA-145a-5p in liver progenitor cells and mice infected with hepatitis B virus X protein (HBx) at different time points to preliminarily explore the mechanism of HBx causing liver tumor.
DU Bin, ZHOU Mengyao, WU Nan, ZHANG Siyao, HUANG Xin, KUANG Qin, WU Yong, FENG Tao   +7 more
doaj   +1 more source

Differential functions of C- and N-terminal hepatitis B x protein in liver cells treated with doxorubicin in normoxic or hypoxic condition. [PDF]

PLoS ONE, 2012
Hepatitis viral B x protein (HBx), a hepatocarcinogen, is frequently mutated. Hypoxia influences the growth of HCC and also the sensitivity of tumor cells to treatments.
Davor Kin-Fan Chau, George Gong Chen, Haitao Zhang, Billy Cheuk Sing Leung, Sukying Chun, Paul Bo-San Lai   +5 more
doaj   +1 more source

Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

Laboratory Animal Research, 2020
The hepatitis B virus (HBV) infects approximately 240 million people worldwide, causing chronic liver disease (CLD) and liver cancer. Although numerous studies have been performed to date, unfortunately there is no conclusive drug or treatment for HBV ...
Dae-Yeul Yu
doaj   +1 more source