Detection of the Hepatitis B Virus X Protein (HBx) Antigen and Anti-HBx Antibodies in Cases of Human Hepatocellular Carcinoma [PDF]
Journal of Clinical Microbiology, 2003 ABSTRACT Hepatitis B virus X protein (HBx) expressed in Escherichia coli DH5α by recombinant DNA technology was purified to homogeneity by use of glutathione-Sepharose beads. Immunological characterization of the recombinant HBx protein was performed.
Guang-Yuh, Hwang +7 more
openaire +2 more sources
The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. [PDF]
PLoS ONE, 2011 Hepatitis B virus (HBV) infection is a major risk for hepatocellular carcinoma (HCC), and it is a serious global health problem with two billion people exposed to it worldwide.
Tatsuo Kido +2 more
doaj +1 more source
Transcriptomic identification of HBx-associated hub genes in hepatocellular carcinoma [PDF]
PeerJ, 2021 Background Hepatocellular carcinoma (HCC) is one of the most common malignancies around the world. Among the risk factors involved in liver carcinogenesis, hepatitis B virus (HBV) X protein (HBx) is considered to be a key regulator in ...
Zhengzhong Ni +8 more
doaj +2 more sources
Neoplasia: An International Journal for Oncology Research, 2013 The infection of hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC), in which HBV X protein (HBx) plays crucial roles.
Tao Zhang +10 more
doaj +1 more source
Hepatitis B x (HBx) as a Component of a Functional Cure for Chronic Hepatitis B
Biomedicines, 2022 Patients who are carriers of the hepatitis B virus (HBV) are at high risk of chronic liver disease (CLD) which proceeds from hepatitis, to fibrosis, cirrhosis and to hepatocellular carcinoma (HCC).
Mark A. Feitelson +3 more
doaj +1 more source
Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication
Cell Reports, 2016 The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function.
Christopher M. Murphy +9 more
doaj +1 more source
Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice [PDF]
, 2009 Identifying the requirements for the regulatory HBx protein in hepatitis B virus (HBV) replication is an important goal. A plasmid-based HBV replication assay was used to evaluate whether HBx subcellular localization influences its ability to promote ...
Hodgson, Amanda J. +3 more
core +1 more source
, 2017 Maspin suppresses tumor progression by promoting cell adhesion and apoptosis and by inhibiting cell motility. However, its role in tumorigenesis of hepatocellular carcinoma (HCC) remains unclear.
Chen, Wen-Shu;Yen, Chia-Jui;Chen, Yun-Ju;Chen, Jhen-Yu;Wang, Li-Yun;Chiu, Shu-Jun;Shih, Wen-Ling;Ho, Chien-Yi;Wei, Tzu-Tang;Pan, Hsiao-Lin;Chien, Pei-Hsuan;Hung, Mien-Chie;Chen, Ching-Chow;Huang, Wei-Chien +1 more
core +1 more source
Modulation of Apoptotic Signaling by the Hepatitis B Virus X Protein
Viruses, 2012 Worldwide, an estimated 350 million people are chronically infected with the Hepatitis B Virus (HBV); chronic infection with HBV is associated with the development of severe liver diseases including hepatitis and cirrhosis.
Michael J. Bouchard +2 more
doaj +1 more source
HBx-Derived Constrained Peptides Inhibit the Secretion of Hepatitis B Virus Antigens
, 2018 Hepatitis B virus (HBV) infection is the primary cause of cirrhosis and liver cancer. Protein–protein interactions (PPIs) between HBV x protein (HBx) and its host targets, including Bcl-2, are important for cell death and viral replication. No modulators
Xiaodong Shi +11 more
core +1 more source