Results 41 to 50 of about 9,710 (220)

Role of the HBx oncoprotein in carbonic anhydrase 9 induction

Journal of Medical Virology, 2009
AbstractCarbonic anhydrase 9 (CA9), as one of the most hypoxia‐responsive genes, has been associated almost exclusively with hypoxic tumors. Its principal role is in pH regulation which helps tumor cells overcome intracellular acidosis and survive extended periods of time with low oxygen.
Holotnakova, Tereza, Tylkova, Lucia, Takacova, Martina, Kopacek, Juraj, Petrik, Juraj, Pastorekova, Silvia, Pastorek, Jaromir   +6 more
openaire   +3 more sources

Id-1 Induces Proteasome-dependent Degradation of the HBX Protein

, 2008
Id-1 is a member of the HLH protein family that regulates a wide range of cellular processes such as cell proliferation, apoptosis, senescence and overexpression of Id-1 was recently suggested to play roles in the development and progression of different
Wang, X, Wong, YC, Lee, TKW, Chiu, Yung-Tuen, Chiu, YT, Ling, MT, Wong, KF, Leung, SCL, Wang, Xiang-Hong, Leung, Steve, Ling, Patrick, Lee, Terence, Fung, Maggie, Wong, Yong Chuan, Fung, MKL, Wong, Kwong Fai   +15 more
core   +1 more source

Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway

Cellular Physiology and Biochemistry, 2016
Background/Aims: The hepatitis B virus X protein (HBx) contributes to HBV-induced injury of renal tubular cells and induces apoptosis via Fas/FasL up-regulation. However, the mechanism of Fas/FasL activation is unknown.
Ping He, Beiru Zhang, Dajun Liu, Xiaohui Bian, Detian Li, Yanqiu Wang, Guangping Sun, Guangyu Zhou   +7 more
doaj   +1 more source

HBx and SP1 upregulate DKK1 expression.

Acta Biochimica Polonica, 1970
Numerous evidences suggested that the hepatitis B virus (HBV) was recognized as an important factor in the development of hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) recently was reported to be involved in the progress of HCC. HBV may regulate DKK1 expression in hematoma carcinogenesis.
Hong, Peng, Yongguo, Li, Yunzhi, Liu, Jingnan, Zhang, Ke, Chen, Ailong, Huang, Hua, Tang   +6 more
openaire   +3 more sources

Spindlin1 interacts with HBx.

, 2014
(A) Coimmunoprecipitation of His-myc-Spindlin1 (His-myc-Spin1) with HA-HBx using anti-Myc antibodies in HEK293 cells. Proteins in the immune complexes were revealed by Western blotting with anti-His and anti-HA antibodies. The expression of β-catenin was
Christine Neuveut (628624), Shirine Benhenda (628622), O. John Semmes (10402), Aurélie Ducroux (628621), Monsef Benkirane (151658), Lise Rivière (628623)   +5 more
core   +1 more source

14‐3‐3ζ binds to hepatitis B virus protein X and maintains its protein stability in hepatocellular carcinoma cells

Cancer Medicine, 2018
14‐3‐3ζ, a phosphopeptide‐binding molecule, is reportedly overexpressed in the cancerous tissues of patients with hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) protein X (HBx) draws intensive attention in HBV‐related HCC because it not only ...
Yufu Tang, Yibing Zhang, Chunhui Wang, Zhongyi Sun, Longfei Li, Jiahong Dong, Wenping Zhou   +6 more
doaj   +1 more source

Hepatitis B virus x protein induces epithelial-mesenchymal transition of hepatocellular carcinoma cells by regulating long non-coding RNA

Virology Journal, 2017
Background It has been widely accepted that hepatitis B virus X protein (HBx) plays an important role in hepatocellular carcinoma (HCC). This study aimed to explore the function of long non-coding RNAs (lncRNAs) in the epithelial-mesenchymal transition ...
Yinji Jin, Di Wu, Weiwei Yang, Mingjiao Weng, Yafei Li, Xuefei Wang, Xiao Zhang, Xiaoming Jin, Tianzhen Wang   +8 more
doaj   +1 more source

HBx increases SOCS3 expression.

, 2013
(A) The protein and mRNA expression of SOCS3 in wild-type and HBx-transgenic mice in a stage-specific manner. The liver tissues of control mice and HBx homozygous transgenic mice were immunoblotted with anti-SOCS3 antibody.
JaeHun Cheong (366273), KyeongJin Kim (366271), Kook Hwan Kim (366272)   +2 more
core   +1 more source

Selective Nitrate Transmembrane Transport Through Adaptive Weak C─H Bonding Cyanostilbene Water Channels

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Here we demonstrate that weak HB CH donor cyanostilbenes promote water/ion transport through their ability to form less‐ordered transient water channels within the lipid bilayer with increased water permeability and NO3−/ Cl− selectivity. ABSTRACT Transmembrane water transport strongly depends on how dynamic, translocating water clusters are stabilized
Ioan Stroia, Dan‐Dan Su, Yuhao Li, Niculina Hadade, Ion Grosu, Arie van der Lee, Mihail Barboiu   +6 more
wiley   +2 more sources

Crosstalk between hepatitis B virus X and high‐mobility group box 1 facilitates autophagy in hepatocytes

Molecular Oncology, 2018
Hepatitis B virus (HBV) X (HBx) protein is a pivotal regulator of HBV‐triggered autophagy. However, the role of HBx‐induced epigenetic changes in autophagy remains largely unknown.
Sha Fu, Juan Wang, Xingwang Hu, Rong‐rong Zhou, Yongming Fu, Daolin Tang, Rui Kang, Yan Huang, Lunquan Sun, Ning Li, Xue‐Gong Fan   +10 more
doaj   +1 more source